Aspirin cures erythromelalgia and cerebrovascular disturbances in JAK2-thrombocythemia through platelet-cycloxygenase inhibition

Figure 12 Pathophysiology of erythromelalgia as multicellular processes caused by platelet mediated microvascular erythromelalgic arteriolar inflammation and thrombosis in myeloproliferative thrombocythemia vera and major arterial thrombotic disease in polycythemia vera. Shear induced production of prostaglandin endoperoxides from activated platelets in arterioles account for red warm congested swelling. Platelet derived growth fator (PDGF) released during platelet secretion can readily explain the fibromuscular intimal proliferation of areterioles first descibed by Michiels in 1981 and published by Michiels et al[52,53] in 1984 and 1985. Right: Platelet counts in 99 case histories of erythromelalgia thrombotic thrombocythemia (ETT) subdivided in ET (n = 69) and PV (n = 30) and in 100 case histories with hemorrhagic thrombocythemia (HT), Source Michiels 1981.