Aspirin cures erythromelalgia and cerebrovascular disturbances in JAK2-thrombocythemia through platelet-cycloxygenase inhibition

Figure 5 Planimetry of megakaryocyte sizes (μm²) from bone marrow smears in controls, polycythemia vera and chronic granulocytic leukemia upper left: Normal size megakaryocytes in controls; large megakaryocytes in untreated polycythemia vera and small sized megakaryocytes in chronic granulocytic leukemia (Frantzen et al[40]). Demonstration by Michiels (1981) of a spectrum of clustered large megakaryocytes with hyperlobulated nuclei and a normocellular bone marrow in essential thrombocythemia (ET) vs increased bone marrow cellularity duet o increased erythropoiesis in ET and polycythemia vera (PV) vs increased trilinear eythrocythemic, megakaryocythemia and granulocythemic (EMG) proliferation in classical PV according to Dameshek[38] (1950) and Kurnicke et al[39].