European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms

Figure 19 Clinical case of calcireticulin positive myelofibrosis: Hemoglobin 11. 2 g/dL, hematocrit 0.33, leukocytes 9.2 × 10⁹/L, platelets 347 × 10⁹/L, lactodehydrogenase 1393 U/L, and the presence of tear drop erythrocytes, poikolocytosis and polychromasie in a peripheral bloodsmear, and hypercellular bone marrow with relative decrease of erythropoisis, dense cluster of immature megakaryocytes with hypolobulated nuclei consistent, and reticulin fibrosis grade 2 consistent with bone marrow histology features similar to World Health Organization-defined primary myelofibrosis, but distinct from JAK2^V617F mutated essential thrombocythemia and polycythemia vera, and distinct from MPL⁵¹⁵ mutated essential thrombocythemia (Figures 17).