European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms

Figure 4 Cluster of medium and large immature megakaryocytes (350 × left) and large megakaryocytes with immature cytoplasm and immature clumpsy cloudlike nuclei (pseudolobulation) (right 900 ×) and very slight reticulin fibrosis in chronic megakaryocytic granulocytic myeloproliferation, and characteristics of megakaryocytes in prefibrotic myeloproliferative disorders: myeloproliferaive disease, 900 × plastic embedding. A: Small and large and immature cloud-like nuclei in chronic megakaryocytic granulocytic myelosis or primary megakaryocytic granulocytic myeloproliferatio; B: Pleomorp large megakaryocytes in Polycythemia Vera; C: Deep hyperlobulated nuclei in essential thrombocythemia. Georgii et al[35,36].