European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms

Figure 2 Reciprocal translocation t(9;22)(q34;q11) creates a novel breakpoint cluster region/ABL fusion gene with high tyrosinase activity as the cause of chronic myeloid leukemia. A: Dr. Janet Rowley, discoverer of t(9;22)(q34;q11) in Ph1chromosome positive chronic myeloid leukemia (CML)[19,20], and winner the Beutler Prize 2011, American Society of Hematology (ASH). Photo courtesy of ASH 2012; B: The discoverers of BCR/ABL fusion gene as the cause of Ph+ CML[21-24]. From left behind to right Gerard Grosveld, John Groffen and Nora Heisterkamp.