PVSG and WHO vs European Clinical, Molecular and Pathological Criteria for prefibrotic myeloproliferative neoplasms

Figure 7 Thirty-seven-years old woman (asymptomatic except fatigue) with JAK2 wild type hypercellular essential thrombocythemia: platelets 1205 × 10⁹/L, Hb 12. 5 g/dL, erythrocytes 4.9 × 10¹²/L, leukocytes 18 × 10⁹/L, slightly increased lactodehydrogenase, no splenomegaly on palpation as the presenting features of primary megakaryocytic and granulocytic myeloproliferation (Table 5). A, B, D-F: JAK2 wild type hypercellular bone marrow histology due to primary megakaryocytic and granulocytic myeloproliferation with the presence of clustered atypical giant to medium sized dysmorphic megakaryocytes containing bulky (cloud-like) hypolobulated nuclei and definitive maturation defects; C: Reticulin fibrosis grade 2.