Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera

Figure 11 Bone marrow histomorphology from a patient with early prefibrotic polycythemia vera at diagnosis in 1996 (A) (hemoglobin 19. 7 g/dL, hematoctit 0.60. leukocytes normal, platelets 750 × 10⁹/L, modest splenomegaly, JAKV617F > 54%) just prior to interferon α-2b treatment (B) showing typical hypercellular polycythemia vera pictures with clustered large pleiomorphic megakaryocytes and normal cellular bone marrow with megakaryocytes of normal size and morphology (JAK2V617F < 1%) after 8 years of treatment with interferon α-2b treatment (C). Courtesy of Hans Hasselbalch, Denmark. A and B: Pleiomorphic (normal sized and enlarged ) loosely clustered megakaryocytes with hyperploid nuclei and increased cellularity due to increased erythropoiesis in a case of polycythemia vera (PV) before start of interferon α-2b treatment in 1996; C: Megakaryocytes of normal size and morphology in a normocellular bone marrow in the case of PV (A, B) in complete hematological and molecular remission. Originated from Larsen et al[98].