Published online Aug 15, 2023. doi: 10.4239/wjd.v14.i8.1280
Peer-review started: April 19, 2023
First decision: April 28, 2023
Revised: May 16, 2023
Accepted: June 21, 2023
Article in press: June 21, 2023
Published online: August 15, 2023
Processing time: 114 Days and 2.6 Hours
The background of the research is the increasing prevalence and challenges associated with type 2 diabetes mellitus (T2DM). The study explores the causes of T2DM and the limitations of current treatment options.
The motivation behind the research is to address the limitations of existing drugs for T2DM treatment and explore the potential of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as a more effective therapeutic option.
The objectives of the research are to compare the blood glucose control effects of weekly and daily formulations of GLP-1RAs, analyze glucose excursion and inflammation in overweight or obese patients with T2DM, and evaluate the safety and clinical application prospects of the weekly formulation.
The study involved administering weekly and daily formulations of GLP-1RA to the participants and measuring various parameters such as fasting blood glucose, mean blood glucose, glucose excursion, lipid levels, and inflammation markers. Glucose dynamic tests were conducted to assess blood glucose fluctuations.
The results indicated that the weekly formulation of GLP-1RA had superior blood glucose control effects compared to the daily formulation. It resulted in lower mean blood glucose levels, reduced glucose excursion, and improved lipid profiles. Additionally, the weekly formulation showed a greater decrease in inflammation markers.
Based on the findings, the research concludes that the weekly formulation of GLP-1RA is more effective in controlling blood glucose levels, inhibiting inflammation, and reducing adverse reactions in obese patients with T2DM. It suggests that the weekly formulation has promising clinical applications and should be considered for wider implementation.
To investigate the effects of weekly and daily formulations of GLP-1RA on glucose excursion and inflammation in overweight and obese patients with type 2 diabetes.