Published online Aug 15, 2023. doi: 10.4239/wjd.v14.i8.1249
Peer-review started: May 21, 2023
First decision: June 1, 2023
Revised: June 30, 2023
Accepted: July 17, 2023
Article in press: July 17, 2023
Published online: August 15, 2023
Obesity usually causes diabetes mellitus (DM) and endangers human health seriously, and type 2 DM (T2DM) usually occurs along with obesity. Foodborne obesity-induced DM is caused by the excessive long-term diet and surplus energy.
Bariatric surgery can improve the symptoms of T2DM in some obese patients, but different types of bariatric surgery may have different effects.
To investigate the effect of different types of bariatric surgery on glucose and lipid metabolism, and liver and kidney function in rats, and to explore the underlying mechanisms.
Male Sprague-Dawley rats aged 6-8 wk underwent Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), or gastric banding (GB). Glucose and insulin tolerance tests, analysis of biochemical parameters, histological examination, western blot, and quantitative real-time polymerase chain reaction were conducted.
In comparison to the sham operation group, the RYGB, SG, and GB groups had decreased body weight and food intake, reduced glucose intolerance and insulin insensitivity, downregulated biochemical parameters, alleviated morphological changes in the liver and kidneys, and decreased levels of protein kinase C (PKC)β/P66shc. Among the three groups, the effect in the RYGB group was better than that in the SG and GB groups.
Bariatric surgeries, including RYGB, SG, and GB, can modulate the glucose and lipid metabolism, and liver and kidney function in food-derived obese diabetic rats via mediating the PKCβ/P66shc pathway.
Bariatric surgery may be helpful for the treatment of foodborne obesity-induced DM.