Published online Aug 15, 2023. doi: 10.4239/wjd.v14.i8.1249
Peer-review started: May 21, 2023
First decision: June 1, 2023
Revised: June 30, 2023
Accepted: July 17, 2023
Article in press: July 17, 2023
Published online: August 15, 2023
Obesity usually causes diabetes mellitus (DM) and is a serious danger to human health. Type 2 DM (T2DM) mostly occurs along with obesity. Foodborne obesity-induced DM is caused by an excessive long-term diet and surplus energy. Bariatric surgery can improve the symptoms of T2DM in some obese patients. But different types of bariatric surgery may have different effects.
To investigate the effect of bariatric surgery on glucose and lipid metabolism and liver and kidney function in rats.
Male Sprague-Dawley rats aged 6-8 wk underwent Roux-en-Y gastric bypass surgery (RYGB), sleeve gastrectomy (SG), or gastric banding (GB). Glucose and insulin tolerance tests, analyses of biochemical parameters, histological examina
In comparison to the sham operation group, the RYGB, SG, and GB groups had decreased body weight and food intake, reduced glucose intolerance and insulin insensitivity, downregulated biochemical parameters, alleviated morphological changes in the liver and kidneys, and decreased levels of protein kinase C β/ P66shc. The effect in the RYGB group was better than that in the SG and GB groups.
These results suggest that RYGB, SG and GB may be helpful for the treatment of foodborne obesity-induced DM.
Core Tip: Bariatric surgery can improve the symptoms of type 2 diabetes mellitus (DM) in some obese patients. But different types of bariatric surgery may have different effects. In the current study, in comparison to the sham operation group, the Roux-en-Y gastric bypass surgery (RYGB), sleeve gastrectomy (SG), and gastric banding (GB) groups had decreased body weight and food intake, reduced glucose intolerance and insulin insensitivity, downregulated biochemical parameters, alleviated morphological changes in the liver and kidneys, and decreased levels of protein kinase C β/P66shc. The effect in the RYGB group was better than that in the SG and GB groups. Thus, bariatric surgeries are a helpful tool for the treatment of foodborn obesity-induced DM.