Long H, Zhao L, Xiao ZS, Li SX, Huang QL, Xiao S, Wu LL. Impact of bariatric surgery on glucose and lipid metabolism and liver and kidney function in food-induced obese diabetic rats. World J Diabetes 2023; 14(8): 1249-1258 [PMID: 37664479 DOI: 10.4239/wjd.v14.i8.1249]
Corresponding Author of This Article
Liang-Liang Wu, MM, Attending Doctor, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, No. 69 Chuanshan Road, Shigu District, Hengyang 421001, Hunan Province, China. 2018012015@usc.edu.cn
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Aug 15, 2023; 14(8): 1249-1258 Published online Aug 15, 2023. doi: 10.4239/wjd.v14.i8.1249
Impact of bariatric surgery on glucose and lipid metabolism and liver and kidney function in food-induced obese diabetic rats
Hong Long, Lei Zhao, Zhong-Sheng Xiao, Shu-Xiang Li, Qiu-Lin Huang, Shuai Xiao, Liang-Liang Wu
Hong Long, Lei Zhao, Zhong-Sheng Xiao, Shu-Xiang Li, Qiu-Lin Huang, Shuai Xiao, Liang-Liang Wu, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
Author contributions: Long H, Zhao L, Li SX, and Wu LL designed the research; Long H and Wu LL performed the research and wrote the paper; Zhao L, Huang QL, and Xiao S supervised the report; Li SX contributed to the data analysis; Xiao ZS provided clinical advice.
Supported bythe Natural Science Foundation of Hunan Province, No. 2021JJ70119.
Institutional animal care and use committee statement: All experimental procedures performed on animals were in accordance with the guidelines of the Animal Ethics Committee of Hunan Evidence-based Biotechnology Co.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Experimental data for this study can be obtained from the corresponding author.
ARRIVE guidelines statement: All authors read the ARRIVE guidelines, and this manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liang-Liang Wu, MM, Attending Doctor, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, No. 69 Chuanshan Road, Shigu District, Hengyang 421001, Hunan Province, China. 2018012015@usc.edu.cn
Received: May 21, 2023 Peer-review started: May 21, 2023 First decision: June 1, 2023 Revised: June 30, 2023 Accepted: July 17, 2023 Article in press: July 17, 2023 Published online: August 15, 2023 Processing time: 82 Days and 8.6 Hours
Abstract
BACKGROUND
Obesity usually causes diabetes mellitus (DM) and is a serious danger to human health. Type 2 DM (T2DM) mostly occurs along with obesity. Foodborne obesity-induced DM is caused by an excessive long-term diet and surplus energy. Bariatric surgery can improve the symptoms of T2DM in some obese patients. But different types of bariatric surgery may have different effects.
AIM
To investigate the effect of bariatric surgery on glucose and lipid metabolism and liver and kidney function in rats.
METHODS
Male Sprague-Dawley rats aged 6-8 wk underwent Roux-en-Y gastric bypass surgery (RYGB), sleeve gastrectomy (SG), or gastric banding (GB). Glucose and insulin tolerance tests, analyses of biochemical parameters, histological examination, western blot, and quantitative real-time polymerase chain reaction were conducted.
RESULTS
In comparison to the sham operation group, the RYGB, SG, and GB groups had decreased body weight and food intake, reduced glucose intolerance and insulin insensitivity, downregulated biochemical parameters, alleviated morphological changes in the liver and kidneys, and decreased levels of protein kinase C β/ P66shc. The effect in the RYGB group was better than that in the SG and GB groups.
CONCLUSION
These results suggest that RYGB, SG and GB may be helpful for the treatment of foodborne obesity-induced DM.
Core Tip: Bariatric surgery can improve the symptoms of type 2 diabetes mellitus (DM) in some obese patients. But different types of bariatric surgery may have different effects. In the current study, in comparison to the sham operation group, the Roux-en-Y gastric bypass surgery (RYGB), sleeve gastrectomy (SG), and gastric banding (GB) groups had decreased body weight and food intake, reduced glucose intolerance and insulin insensitivity, downregulated biochemical parameters, alleviated morphological changes in the liver and kidneys, and decreased levels of protein kinase C β/P66shc. The effect in the RYGB group was better than that in the SG and GB groups. Thus, bariatric surgeries are a helpful tool for the treatment of foodborn obesity-induced DM.
