Computed tomography fluoroscopy guided percutaneous lung biopsy for ground-glass opacity pulmonary lesions: A meta-analysis

Table 1 Characteristics of the included four studies

Ref.	Year	Lesion size (mm)	tp	fp	fn	tn	All	Complications
Hur et al[6]	2009	≤ 10	4	0	2	4	10	Pneumothorax (5);
		11-20	5	0	2	3	10	Hemoptysis (3); Thoracostomy tube insertion (2)
		> 20	3	0	1	4	8
		All	12	0	5	11	28
Yamauchi et al[7]	2011	≤ 10	6	0	1	1	8	Pneumothorax (14); Hemoptysis (13); Thoracostomy tube insertion (0)
		11-20	36	0	1	5	42
		> 20	17	0	0	0	17
		All	59	0	2	6	67
Inoue et al[8]	2012	≤ 10	21	0	1	2	24	Pneumothorax (30); Hemoptysis (7); Thoracostomy tube insertion (1); Air embolism (1)
		11-20	36	0	2	3	41
		> 20	1	0	0	0	1
		All	58	0	3	5	66
Yamagami et al[9]	2013	≤ 10	16	0	4	11	31	Pneumothorax (44); Hemoptysis (9); Thoracostomy tube insertion (3)
		11-20	30	0	4	6	40
		> 20	12	0	0	2	14
		All	58	0	8	19	85

fn: False negative; fp: False positive; tn: True negative; tp: True positive.

Table 2 Subgroup analysis of the included four studies

Size	Sen	Spe	+LR	-LR	DOR	SROC
All	0.91 (0.86-0.95)	1.0 (0.91-1.0)	18.64 (4.83-71.93)	0.11 (0.05-0.26)	153.17 (30.78-762.33)	0.98
≤ 10 mm	0.85 (0.73-0.94)	1.0 (0.81-1.0)	8.03 (2.21-29.18)	0.24 (0.14-0.41)	37.94 (7.48-192.37)	0.92
11-20 mm	0.92 (0.86-0.96)	1.0 (0.80-1.0)	9.35 (2.45-35.71)	0.13 (0.08-0.22)	67.98 (13.06-353.87)	0.96
> 20 mm	0.94 (0.70-1.0)	1.0 (0.54-1.0)	6.24 (0.97-40.0)	0.20 (0.07-0.60)a	38.93 (2.80-541.16)b	-c

^a,bOnly studies 6 and 9 were calculated;

^cSROC for GGO > 20 mm could not be calculated in this meta-analysis because of only two data points. Sen: Sensitivity; Spe: Specificity; +LR: Positive likelihood ratio; -LR: Negative likelihood ratio; DOR: Diagnostic odds ratio; SROC: Summary receiver operating characteristic; GGO: Ground-glass opacity.