Meta-Analysis
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Apr 26, 2016; 4(2): 55-62
Published online Apr 26, 2016. doi: 10.13105/wjma.v4.i2.55
Computed tomography fluoroscopy guided percutaneous lung biopsy for ground-glass opacity pulmonary lesions: A meta-analysis
Gao-Wu Yan, Gao-Wen Yan, Qin-Quan Sun, Xiang-Ke Niu, Bing Li, Anup Bhetuwal, Xiao-Xue Xu, Yong Du, Han-Feng Yang
Gao-Wu Yan, Qin-Quan Sun, Bing Li, Anup Bhetuwal, Xiao-Xue Xu, Yong Du, Han-Feng Yang, Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Gao-Wen Yan, Department of Radiology, the First People’s Hospital of Suining City, Suining 629000, Sichuan Province, China
Xiang-Ke Niu, Department of Radiology, Affiliated Hospital of Chengdu University, Chengdu 610000, Sichuan Province, China
Author contributions: Yan GW, Yan GW and Yang HF designed the research; Niu XK and Li B performed the research; Sun QQ, Xu XX and Du Y analyzed the data; Yan GW, Yan GW and Yang HF wrote the paper; Yan GW and Yang HF contributed equally to this work; Bhetuwal A proofread the English.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Han-Feng Yang, MD, PhD, Professor, Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong 637000, Sichuan Province, China. 505254007@qq.com
Telephone: +86-817-2262089
Received: November 30, 2015
Peer-review started: December 1, 2015
First decision: December 28, 2015
Revised: February 2, 2016
Accepted: February 23, 2016
Article in press: February 24, 2016
Published online: April 26, 2016
Processing time: 135 Days and 13.7 Hours
Abstract

AIM: To obtain the diagnostic performance of percutaneous transthoracic needle biopsy (PTNB) under Computed tomography (CT) fluoroscopy guidance for lung ground-glass opacity (GGO).

METHODS: We searched for English- and Chinese-language studies in PubMed, EMBASE, EBSCO, OVID, and CNKI (China National Knowledge Infrastructure) database. Data were calculated with Meta-Disc version 1.4 and Rev Man version 5.2 software. From the pooled data, we calculated sensitivity (Sen), specificity (Spe), positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (DOR). Summary receiver operating characteristic (SROC) curves were constructed and incidence of complications was recorded.

RESULTS: Four documents included in this present meta-analysis met the criteria for analysis. The pooled Sen, Spe, +LR, -LR and DOR with 95%CI were 0.91 (0.86-0.95), 1.0 (0.91-1.0), 18.64 (4.83-71.93), 0.11 (0.05-0.26) and 153.17 (30.78-762.33), respectively. The area under the SROC curve was 0.98. The incidence of pneumothorax and hemoptysis was 17.86%-51.80% and 10.50%-19.40%, respectively.

CONCLUSION: CT fluoroscopy-guided PTNB, which has an acceptable incidence of complications, can be used as a primary examination method for lung GGO, with moderate sensitivity and specificity.

Keywords: Lung biopsy; Meta-analysis; Ground-glass opacity; Computed tomography fluoroscopy

Core tip: There is no consensus in the literature about the diagnostic performance of percutaneous transthoracic needle biopsy (PTNB) under Computed tomography (CT) fluoroscopy guidance for lung ground-glass opacity (GGO). We performed a meta-analysis to obtain the diagnostic performance of CT fluoroscopy-guided PTNB of lung GGO in terms of pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and incidence of complications. We also generated a summary receiver operating characteristic curve as a way of summarizing the global test performance of CT fluoroscopy-guided PTNB.