Diagnostic yield of third eye retroscope on adenoma detection during colonoscopy: A systematic review and meta-analysis

Table 1 Characteristics of included studies

Ref.	Location	Study design	Mean patient age(yr)	Sample size	Intervention	Quality score	∆TER/SC		∆TER / SCmean size (range) mm		Mean time (min)
							Polyps	Adenoma	Polyps	Adenoma	Withdrawal	Total
Triadafilo- poulos et al[16] 2008	United States	Prospective, Single center study	64 ± 9.6	(T): 24	SC + TER	23	4/34	1/8	7.5 (2-7)/ 4 (1-15)	7/8 (4-15)	NA	NA
				(M): 16
				(F): 8
Waye et al[14] 2010	United States	Prospective, Multicenter study	63.1 ± 6.5	(T): 249	SC + TER	22	34/257	15/136	5.2 (2-12)/ 4.4 (1-15)	NA	10.9	26
				(M): 132
				(F): 117
DeMarco et al[15] 2010	United States	Prospective, Multicenter study	56.8 ± 11.3	(T): 298	SC + TER	22	27/182	16/100	6.5 (2-13)/ 5.5 (1-40)	6.8 (2-13)/ 6.5 (1-40)	9.9 ± 4.1	24.7 ± 9.7
				(M): 144
				(F): 154
Leufkens et al[13] 20111	Europe and United States	Randomized controlled trial, Multicenter study	Group A: 57.9 ± 9.7	(T): 173	SC → SC + TER	23	78/160	49/107	NA	NA	9.52/7.58	20.87/16.97
				(M): NA
				(F): NA
			Group B: 58.2 ± 9.7	(T): 176	SC + TER → SC		31/163	52/121	NA	NA
				(M): NA
				(F): NA

¹Time TER/SC. SC: Standard colonoscopy; TER: Third eye retroscope; T: Total; F: Female; M: Male; NA: Not available.

Table 2 Results of meta-analysis: Additional polyp detection rate and additional adenoma detection rate

Category	No. of studies	Event rate (%)	95%CI	Heterogeneity
				P	I2(%)
APDR	4	19.8	7.9-41.8	0	96.38
APDR right colon	2	16	11.9-21.2	0.76	0
APDR left colon	2	12.2	8-18	0.22	31.9
APDR 6 mm or more	2	20.9	14.8-28.6	0.47	0
PDR 10 mm or more	2	25.3	15.5-38.4	0.51	0
AADR	4	19.9	7.3-43.9	0	94.44
AADR right colon	2	13.9	9.4-20	0.61	0
AADR left colon	2	10.7	1.9-42	0.02	82
AADR 6 mm or more	2	24.6	16.6-34.9	0.94	0
AADR 10 mm or more	2	24.2	12.9-40.8	0.34	0

APDR: Additional polyp detection rate; AADR: Additional adenoma detection rate.