Meta-Analysis
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Mar 18, 2025; 13(1): 101187
Published online Mar 18, 2025. doi: 10.13105/wjma.v13.i1.101187
Incidence of luminal gastrointestinal cancers in patients with cirrhosis: A systematic review and meta-analysis
Manisha Jogendran, Kai Zhu, Rohit Jogendran, Nasruddin Sabrie, Trana Hussaini, Eric M Yoshida, Daljeet Chahal
Manisha Jogendran, Department of Medicine, Queens's University, Kingston K7L 2V7, ON, Canada
Kai Zhu, Department of Medicine, University of British Columbia, Vancouver 317-2194, BC, Canada
Rohit Jogendran, Nasruddin Sabrie, Department of Medicine, University of Toronto, Toronto 1 King's College Cir M5S 3H2, ON, Canada
Trana Hussaini, BC Liver Transplant Program, Vancouver General Hospital, Vancouver V5Z 1M9, BC, Canada
Eric M Yoshida, Daljeet Chahal, Department of Gastroenterology, University of British Columbia, Vancouver V5Z 1M9, BC, Canada
Co-corresponding authors: Manisha Jogendran and Daljeet Chahal.
Author contributions: Jogendran M, Chahal D designed the research study; Jogendran M, Zhu K, Sabrie N, Jogendran R performed the research; Chahal D, Hussaini T, Yoshida EM contributed new reagents and analytic tools; Jogendran M and Zhu K analyzed the data and wrote the manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All authors have no conflict-of-interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Manisha Jogendran, MD, Doctor, Department of Medicine, Queens's University, 76 Stuart Street, Kingston K7L 2V7, ON, Canada. 13mj5@queensu.ca
Received: September 6, 2024
Revised: October 26, 2024
Accepted: December 12, 2024
Published online: March 18, 2025
Processing time: 188 Days and 15.7 Hours
Core Tip

Core Tip: Very limited data remains studying the association between luminal gastrointestinal cancers and cirrhosis. We showed that overall incidence of gastrointestinal cancers is higher in patients with cirrhosis. Alcohol related cirrhosis had the highest incidence of oral and pharyngeal cancer. Primary biliary cirrhosis did not demonstrate higher incidence of cancer sites.