Yousefi A, Karbalaei M, Keikha M. Impact of Streptococcus pyogenes infection in susceptibility to psoriasis: A systematic review and meta-analysis. World J Meta-Anal 2021; 9(3): 309-316 [DOI: 10.13105/wjma.v9.i3.309]
Corresponding Author of This Article
Masoud Keikha, PhD, Doctor, Instructor, Teaching Assistant, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Qoreishi Center, Daneshgah Street, Mashhad 1313199137, Iran. masoud.keykha90@gmail.com
Research Domain of This Article
Dermatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Meta-Anal. Jun 28, 2021; 9(3): 309-316 Published online Jun 28, 2021. doi: 10.13105/wjma.v9.i3.309
Impact of Streptococcus pyogenes infection in susceptibility to psoriasis: A systematic review and meta-analysis
Amir Yousefi, Mohsen Karbalaei, Masoud Keikha
Amir Yousefi, Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad 1313199137, Iran
Mohsen Karbalaei, Department of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft 09861615881, Iran
Masoud Keikha, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 1313199137, Iran
Author contributions: Keikha M conceived the study; Keikha M provided critical analyses; Keikha M and Karbalaei M analyzed the data; Yousefi A and Karbalaei M wrote the draft; Keikha M revised the draft; All authors read and approved the final manuscript.
Conflict-of-interest statement: The authors have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Masoud Keikha, PhD, Doctor, Instructor, Teaching Assistant, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Qoreishi Center, Daneshgah Street, Mashhad 1313199137, Iran. masoud.keykha90@gmail.com
Received: April 23, 2021 Peer-review started: April 23, 2021 First decision: May 19, 2021 Revised: May 24, 2021 Accepted: June 17, 2021 Article in press: June 17, 2021 Published online: June 28, 2021 Processing time: 79 Days and 15.5 Hours
ARTICLE HIGHLIGHTS
Research background
Psoriasis is a multifactorial autoimmune disease, and it has been suggested that bacterial infection can contribute to the initiation or development of this disease.
Research motivation
We performed this study to discover the association between infection with Streptococcus pyogenes (S. pyogenes) as potential factors and risk of develop to psoriasis.
Research objectives
The objective of this study was to determine the impact of S. pyogenes infection and susceptibility to psoriasis using available case-control studies.
Research methods
We used a computer-assisted comprehensive literature search to obtain relevant case-control regarding to the possible connection between S. pyogenes infection and psoriasis. Finally, the impact of infection with S. pyogenes and susceptibility to psoriasis was measured using odds ratio (OR) with 95% confidence intervals (CIs).
Research results
The rate of infection with S. pyogenes in psoriatic patients vs healthy individuals was 33.4% and 16.2%, respectively. Furthermore, there is a significant association between S. pyogenes infection and development of psoriasis (OR: 6.58; 95%CI: 3.64-11.87; P = 0.001)
Research conclusions
Infection with S. pyogenes is a risk factor for susceptibility to psoriasis.
Research perspectives
Further long-term cohort studies are needed to investigate the relationship between S. pyogenes infection and psoriasis. Also, studies are needed to evaluate the clinical efficacy of the treatment of S. pyogenes infection in decreasing the number of psoriatic events.
