Manuel-Vázquez A, Latorre-Fragua R, de la Plaza-Llamas R, Ramia JM. Hepatic gastrointestinal stromal tumor: Systematic review of an exceptional location. World J Meta-Anal 2019; 7(5): 224-233 [DOI: 10.13105/wjma.v7.i5.224]
Corresponding Author of This Article
Alba Manuel Vázquez, MD, PhD, Doctor, Surgeon, Surgical Oncologist, General and Digestive Surgery, University Hospital of Guadalajara, Calle donante de sangre s/n, Guadalajara 19002, Spain. alba_manuel_vazquez@hotmail.com
Research Domain of This Article
Surgery
Article-Type of This Article
Systematic Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Meta-Anal. May 31, 2019; 7(5): 224-233 Published online May 31, 2019. doi: 10.13105/wjma.v7.i5.224
Hepatic gastrointestinal stromal tumor: Systematic review of an exceptional location
Alba Manuel-Vázquez, Raquel Latorre-Fragua, Roberto de la Plaza-Llamas, José Manuel Ramia
Alba Manuel-Vázquez, Raquel Latorre-Fragua, Roberto de la Plaza-Llamas, José Manuel Ramia, General and Digestive Surgery, University Hospital of Guadalajara, Guadalajara 19002, Spain
Author contributions: Manuel-Vázquez A designed the study, performed the research, analyzed data and wrote the paper. Latorre-Fragua R performed the research, analyzed and interpreted of data. de la Plaza-Llamas R critically reviewed. Ramia JM critically reviewed, finally approved and supervised the report.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Alba Manuel Vázquez, MD, PhD, Doctor, Surgeon, Surgical Oncologist, General and Digestive Surgery, University Hospital of Guadalajara, Calle donante de sangre s/n, Guadalajara 19002, Spain. alba_manuel_vazquez@hotmail.com
Telephone: +34-949-209200
Received: April 3, 2019 Peer-review started: April 3, 2019 First decision: April 30, 2019 Revised: May 11, 2019 Accepted: May 22, 2019 Article in press: May 26, 2019 Published online: May 31, 2019 Processing time: 58 Days and 20.9 Hours
ARTICLE HIGHLIGHTS
Research background
A minor subset of primary gastrointestinal stromal tumors (GIST) can also arise outside the gastrointestinal tract, which is known as an extra-GIST (E-GIST).
Research motivation
Primary GIST of the liver is an exceptional location and this study aimed to characterize epidemiological, clinical and pathological features and options of treatments.
Research objectives
Our aim is to characterize epidemiological, clinical and pathological features and options of treatments.
Research methods
We perform a system review including all patients with hepatic GISTs.
Research results
This review shows that right hepatic lobe was the most frequent location, the median size was higher, there was a Southeast Asian predominance, and nearly 50% of patients have no symptoms. The most frequent treatment was surgery and more than 70% of patients had a lesion with high risk of malignancy.
Research conclusions
Literature on hepatic EGIST is scarce and further studies such as multicentric databases are needed to clarify diagnosis and treatment.
