Abdullah AA, Ahmed M, Oladokun A. Leptin levels in women with unexplained infertility: A systematic review and meta-analysis. World J Meta-Anal 2022; 10(1): 37-45 [DOI: 10.13105/wjma.v10.i1.37]
Corresponding Author of This Article
Abdullah Abdulslam Abdullah, MSc, Academic Research, Lecturer, Department of Reproductive Health Sciences, Pan African University Life and Earth Sciences Institute, University of Ibadan, Ibadan 119, Oyo State, Nigeria. bahlol32029@gmail.com
Research Domain of This Article
Reproductive Biology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Meta-Anal. Feb 28, 2022; 10(1): 37-45 Published online Feb 28, 2022. doi: 10.13105/wjma.v10.i1.37
Leptin levels in women with unexplained infertility: A systematic review and meta-analysis
Abdullah Abdulslam Abdullah, Musa Ahmed, Adesina Oladokun
Abdullah Abdulslam Abdullah, Musa Ahmed, Department of Reproductive Health Sciences, Pan African University Life and Earth Sciences Institute, University of Ibadan, Ibadan 119, Oyo State, Nigeria
Abdullah Abdulslam Abdullah, Department of Biomedical Sciences, Faculty of Veterinary Sciences, University of Gadarif, Gadarif 208, Sudan
Musa Ahmed, Department of Veterinary Surgery, Faculty of Veterinary Medicine, AL-Salam University, Al-Fulla 209, West Kordofan, Sudan
Adesina Oladokun, Department of Obstetrics and Gynecology, Department of Epidemiology, University College Hospital, Ibadan 119, Oyo state, Nigeria
Author contributions: Abdullah AA, Ahmed M, and Oladokun A conceived and designed the review, developed the search strings, screened and selected the studies, and drafted the manuscript, and Oladokun A rigorously reviewed the manuscript; Abdullah AA is the guarantor of the review; Abdullah AA and Ahmed M extracted the data, evaluated the quality of the studies, and carried out analysis and interpretation.
Conflict-of-interest statement: The authors declare no potential conflict of interest concerning the research, authorship, and/or publication of this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abdullah Abdulslam Abdullah, MSc, Academic Research, Lecturer, Department of Reproductive Health Sciences, Pan African University Life and Earth Sciences Institute, University of Ibadan, Ibadan 119, Oyo State, Nigeria. bahlol32029@gmail.com
Received: November 22, 2021 Peer-review started: November 22, 2021 First decision: December 10, 2021 Revised: December 17, 2021 Accepted: January 27, 2022 Article in press: January 27, 2022 Published online: February 28, 2022 Processing time: 97 Days and 16.5 Hours
ARTICLE HIGHLIGHTS
Research background
Despite many breakthroughs in the field of infertility diagnosis and treatment, there are still some infertility cases with unknown causes (unexplained infertility). To overcome this diagnostic issue, many serum biomarkers have been used as predictive markers for unexplained infertility in females.
Research motivation
Leptin is one of the most accurate biomarkers for unexplained infertility. Nevertheless, conflicting results regarding leptin levels in women with unexplained infertility have been reported.
Research objectives
The objective of this study was to conduct a systematic review and meta-analysis to find the serum leptin levels in women with unexplained infertility.
Research methods
A systematic literature search was conducted before April 30, 2021 from PubMed/MEDLINE, Embase, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Google Scholar, OpenGrey, OATD, and the infertility conferences abstract.
Research results
A total of six articles were included in this meta-analysis after 15 articles had been subjected to full-text evaluations.
Research conclusions
Leptin could be a potential biomarker for unexplained infertility in women.
Research perspectives
The effect of other adipokines should be evaluated in future studies to find their possible relation with female infertility.
