Luan D, Wu ZY, Zhang YX, Yuan LL, Xu Y, Chu ZH, Ma LS, Wang YP, Zhao SC. Effect of dl-3-n-butylphthalide on infarction volume in animal models of ischemic stroke: A meta-analysis. World J Meta-Anal 2019; 7(7): 358-372 [DOI: 10.13105/wjma.v7.i7.358]
Corresponding Author of This Article
Shou-Cai Zhao, MD, Doctor, Professor, Teacher, Department of Neurology, Yijishan Hospital affiliated to Wannan Medical College, Wuhu 241000, Anhui Province, China. neurozsc@wnmc.edu.cn
Research Domain of This Article
Neurosciences
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Meta-Anal. Jul 31, 2019; 7(7): 358-372 Published online Jul 31, 2019. doi: 10.13105/wjma.v7.i7.358
Effect of dl-3-n-butylphthalide on infarction volume in animal models of ischemic stroke: A meta-analysis
Di Luan, Zheng-Yu Wu, Yuan-Xiang Zhang, Li-Li Yuan, Yang Xu, Zhao-Hu Chu, Ling-Song Ma, Ya-Ping Wang, Shou-Cai Zhao
Di Luan, Li-Li Yuan, Yang Xu, Zhao-Hu Chu, Ling-Song Ma, Ya-Ping Wang, Shou-Cai Zhao, Department of Neurology, Yijishan Hospital affiliated to Wannan Medical College, Wuhu 241000, Anhui Province, China
Zheng-Yu Wu, Yuan-Xiang Zhang, Department of Clinical Pharmacy, Yijishan Hospital affiliated to Wannan Medical College, Wuhu 241000, Anhui Province, China
Author contributions: Luan D, Wu ZY, Zhang YX, Yuan LL, and Zhao SC conceived and designed the study; study searching was done by Luan D and Wu ZY. Further, studies screening and selection was done by Luan D and Wu ZY independently and disagreement was resolved by Zhao SC, Xu Y, Chu ZH, and Ma LS. Luan D and Wu ZY performed data extraction independently. Wang YP did analysis in supervision of Zhao SC. All authors were involved in interpretation of the results. The final draft of this manuscript was done by Luan D and read and approved by all the authors.
Supported bythe National Natural Science Foundation of China, NO. 81701161.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The manuscript is designed as per PRISMA 2009 guideline and checklist is provided as supplementary file.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shou-Cai Zhao, MD, Doctor, Professor, Teacher, Department of Neurology, Yijishan Hospital affiliated to Wannan Medical College, Wuhu 241000, Anhui Province, China. neurozsc@wnmc.edu.cn
Telephone: +86-18505539779
Received: May 10, 2019 Peer-review started: May 14, 2019 First decision: July 26, 2019 Revised: July 27, 2019 Accepted: July 29, 2019 Article in press: July 29, 2019 Published online: July 31, 2019 Processing time: 82 Days and 2.7 Hours
Abstract
BACKGROUND
Ischemic stroke is a frequently-occurring disease in the elderly and characterized by high morbidity and mortality. Dl-3-n-butylphthalide (NBP), a synthetic compound based on natural celery seeds, has potential therapeutic effects on cerebral ischemia, brain trauma, memory impairment, and epilepsy.
AIM
To evaluated the effect of NBP on infarct volume in experimental ischemic stroke.
METHODS
Twenty one relevant literatures were included from the PubMed, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, VIP information database, and Wanfang database, and data on the effect of dl-3-n-butylphthalide on infarction volume in the middle cerebral artery occlusion model were extracted. Statistical analysis was performed using standard mean difference with random effects model of Revman 5.3.
RESULTS
The data of meta-analysis of the 21 studies had suggested that NBP reduced the cerebral infarction volume of middle cerebral artery occlusion model animals compared to the control group significantly [SMD: -3.97, 95%CI: -4.71 to -3.23, P < 0.01; heterogeneity: χ2 = 59.09, df = 20 (P < 0.01); I2 = 66 %].
CONCLUSION
NBP was effective in experimental ischemic stroke.
Core tip: The systematic review of animal research is of great significance in drug development. This study reports for the first time a systematic review and meta-analysis of the effects of butylphthalide on the volume of cerebral infarction in experimental ischemic stroke.
