Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Dec 18, 2024; 12(4): 100726
Published online Dec 18, 2024. doi: 10.13105/wjma.v12.i4.100726
Colon capsule endoscopy polyp detection rate vs colonoscopy polyp detection rate: Systematic review and meta-analysis
Marc Woods, Jonathan Soldera
Marc Woods, Department of Gastroenterology, University of South Wales, Cardiff CF37 1DL, United Kingdom
Jonathan Soldera, Department of Acute Medicine and Gastroenterology, University of South Wales, Cardiff CF37 1DL, United Kingdom
Co-first authors: Marc Woods and Jonathan Soldera.
Author contributions: Woods M and Soldera J participated in the concept and design research, drafted the manuscript and contributed to data acquisition, analysis and interpretation; Soldera J contributed to study supervision; all authors contributed to critical revision of the manuscript for important intellectual content.
Conflict-of-interest statement: The authors declare to have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jonathan Soldera, MSc, PhD, Tutor, Department of Acute Medicine and Gastroenterology, University of South Wales, Llantwit Rd, Pontypridd, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com
Received: August 26, 2024
Revised: November 11, 2024
Accepted: November 22, 2024
Published online: December 18, 2024
Processing time: 109 Days and 19.8 Hours
Abstract
BACKGROUND

Colon capsule endoscopy (CCE) is a modern, non-invasive method for large bowel visualization, offering a less invasive alternative to traditional colonoscopy (TC). While TC remains the gold standard for comprehensive large bowel assessment, including the detection and treatment of various conditions, the effectiveness of CCE in detecting polyps is less established.

AIM

To systematically review and compare the polyp detection rates (PDR) of CCE and TC.

METHODS

A systematic literature search was conducted using four scientific databases: CINAHL, MEDLINE via EBSCO, Cochrane Library, and MEDLINE/PubMed. A standardized search command was utilized to ensure consistency. Full papers were retrieved if they compared PDR between CCE and TC and involved patients over 18 years old. A meta-analysis was then conducted using the meta package in R software.

RESULTS

Initially, 339 articles were identified, with 128 duplicates and 15 non-English articles excluded, leaving 196 for screening. After further exclusions, 9 articles were included in the review. The meta-analysis revealed minimal differences in PDR between CCE and TC. The pooled PDR for TC was 0.61 (95%CI: 0.48–0.72), and for CCE, it was 0.61 (95%CI: 0.48–0.73). The overall comparison of the pooled PDR of both methods was 0.96 (95%CI: 0.90–1.02), indicating that CCE is non-inferior to TC.

CONCLUSION

CCE has emerged as a modern and safe diagnostic alternative to TC for polyp detection, demonstrating non-inferiority when compared to the conventional method.

Keywords: Colon capsule endoscopy; Colonoscopy; Polyp detection rate; Polyp; Adenoma; Colorectal cancer

Core Tip: Colonic polyps are a common finding during colonoscopy. This study is motivated by the necessity for procedural alternatives that ensure both effectiveness and patient acceptance. This is particularly crucial for reaching individuals who may not undergo conventional colonoscopies when recommended. Given that polyps are often asymptomatic but carry malignant potential if not detected and removed. Colon capsule endoscopy is a modern safe alternative to colonoscopy, identifying an optimal diagnostic approach is paramount to maintaining diagnostic quality.