Published online Sep 18, 2023. doi: 10.13105/wjma.v11.i6.253
Peer-review started: December 27, 2022
First decision: January 30, 2023
Revised: March 7, 2023
Accepted: July 10, 2023
Article in press: July 10, 2023
Published online: September 18, 2023
Neoplasms can be considered as a group of aberrant cells that need more vascular supply to fulfill all their functions. Therefore, they promote angiogenesis through the same neovascularization pathway used physiologically. Angiogenesis is a process characterized by a heterogeneous distribution of oxygen caused by the tumor and oxidative stress; the latter being one of the most powerful stimuli of angiogenesis. As a result of altered tumor metabolism due to hypoxia, acidosis occurs. The angiogenic process and oxidative stress can be detected by measuring serum and tissue biomarkers. The study of the mechanisms underlying angio
Core Tip: There are already several reviews in the literature that contribute to understanding angiogenesis and oxidative stress. However, this is the first review to report the latest cellular and molecular mechanisms of angiogenesis pathways while also discussing the genetics and biochemistry of oxidative stress in neoplasms. We also specifically discuss neuroendocrine lung tumors. These discoveries may be useful for new clinical and translational research studies.