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World J Meta-Anal. May 26, 2013; 1(1): 8-9
Published online May 26, 2013. doi: 10.13105/wjma.v1.i1.8
Sirturo (Bedaquiline): The first new anti tubercular drug in decades
Krishna Undela
Krishna Undela, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore 570015, Karnataka, India
Author contributions: Undela K drafted the protocol, did the literature search and wrote the manuscript.
Correspondence to: Mr. Krishna Undela, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore 570015, Karnataka, India. krishnaundela@gmail.com
Telephone: +91-998-6779870 Fax: +91-821-2548359
Received: January 30, 2013
Revised: February 22, 2013
Accepted: March 6, 2013
Published online: May 26, 2013
Processing time: 113 Days and 18 Hours
Abstract

Tuberculosis (TB) is an infection caused by Mycobacterium tuberculosis and is one of the world’s deadliest diseases. Multidrug resistant TB (MDR-TB) is a serious form of TB and it implies resistance for at least two essential first-line agents like, Isoniazid and Rifampicin. The US Food and Drug Administration (FDA) granted accelerated approval to Janseen Therapeutics “Sirturo (Bedaquiline)”, a diarylquinoline anti mycobacterial drug on December 28, 2012 as part of combination therapy in adults (≥ 18 years) to treat MDR-TB when other alternatives are not available. The FDA also granted Sirturo fast track designation, priority review and orphan-product designation. Bedaquiline inhibits mycobacterial ATP (adenosine 5’-triphosphate) synthase, an enzyme that is essential for the generation of energy in Mycobacterium tuberculosis.

Keywords: Multidrug resistant tuberculosis; Bedaquiline; Sirturo

Core tip: The US Food and Drug Administration granted accelerated approval to Janseen Therapeutics “Sirturo (Bedaquiline)”, a diarylquinoline anti mycobacterial drug on December 28, 2012 as part of combination therapy in adults (≥ 18 years) to treat multidrug resistant tuberculosis when other alternatives are not available.