Vancomycin-induced thrombocytopenia in endocarditis: A case report and review of literature

Table 1 Summary of case reports of vancomycin-induced thrombocytopenia

Author (publication year)	Age (yr)	Gender	Indication	Platelet count (109/L)1	Naranjo Score	Treatment	Time for resolution (d)2	Vancomycin-dependentantibodies	Bleeding sign
Present case	26	M	Endocarditis	27	Probable	Platelet transfusion and daptomycin	12	NA	+
MacDougall et al[14] (2020)	81	M	Prosthetic infection	2	NA	Prednisone, immunoglobulin, and daptomycin	10	+	-
Ajit et al[27] (2019)	61	M	Hemodialysis	< 10	NA	Prednisone, immunoglobulin, eltrombopag and plasma exchange	15	+	+
Getz et al[18] (2019)	71	M	Transverse myelitis	8.6	Definite	Dexamethasone and immunoglobulin	8	+	+
Chen et al[16] (2018)	0	F	Purulent meningitis	8	Probable	Methylprednisolone	4	+	+
Danieletto et al[17] (2017)	57	F	Bone graft	9	Probable	Tigecycline	7	-	-
Kalra et al[28] (2016)	0.7	M	Sepsis	30	NA	Platelet transfusion	3	NA	-
Schueler et al[15] (2016)	55	M	Purpura	1	NA	Prednisone and immunoglobulin	3	NA	+
Yamanouchi et al[29] (2016)	72	F	Sepsis	2	NA	Steroid therapy and carbapenem	7	+	+
Lobo et al[13] (2015)	67	M	Pneumonia	2	Probable	Platelet transfusion, methylprednisolone and immunoglobulin	3	+	+
Ahmed et al[30] (2015)	63	M	Diabetic foot	2	Probable	Daptomycin	10	+	-
Candemir et al[10] (2013)	54	F	Hematoma	42	Probable	Platelet transfusion and daptomycin	4	NA	NA
Wetzel et al[31] (2013)	64	F	Sepsis	7	Probable	Prednisone and immunoglobulin	8	NA	+
Ruggero et al[32] (2012)	41	M	Pneumonia	15	Definite	Daptomycin	5	NA	+
Arnold et al[23] (2013)	66	F	Endocarditis	4	Probable	Platelet transfusion and immunoglobulin	5	+	+
Rowland et al[33] (2013)	51	M	Acute pancreatitis	9	Probable	Only vancomycin discontinuation	5	NA	+
Anand et al[34] (2011)	54	M	Cellulitis	1	Possible	Corticosteroids and daptomycin	2	+	+
Ganly et al[22] (2011)	67	M	Sepsis	2	NA	Platelet transfusion and immunoglobulin	8	NA	+
Shah et al[11] (2009)	60	M	Shoulder infection	9	Possible	Platelet transfusion	3	+	+
Lee et al[35] (2009)	76	M	Diabetic foot	< 15	Possible	Platelet transfusion and teicoplanin.	5	+	-
Apiwattanakul et al[36] (2008)	16	F	Endocarditis	123	Possible	Prednisone and cefotaxime	5	NA	-
Kenney et al[20] (2008)	61	M	Gangrene and bacteremia	3	Probable	Platelet transfusion and immunoglobulin	4	+	+
Pauldine et al[37] (2008)	60	M	Pneumonia	10	Possible	Platelet transfusion	12	+	+
Dilli et al[38] (2008)	0.6	M	Neonatal respiratory distress	41	NA	Only vancomycin discontinuation	3	-	NA
O’Donnell et al[21] (2007)	56	F	Prosthetic infection	2	Possible	Immunoglobulin	7	+	+
Bay et al[39] (2006)	2	M	Pneumonia	11	NA	Only vancomycin discontinuation	4	NA	NA
Winteroll et al[24] (2004)	72	M	Sepsis	3	Probable	Platelet transfusion	10	+	+
Peel et al[40] (2003)	45	M	Peritonitis	5	Probable	Platelet transfusion and prednisone	4	NA	+
Marraffa et al[41] (2003)	50	M	Endocarditis	10	Probable	Clindamycin and methylprednisolone	5	NA	+
Rocha et al[42] (2002)	38	F	Prosthetic infection	68	Possible	Only vancomycin discontinuation	4	NA	NA
Shahar et al[43] (2000)	43	F	Surgery-site infection	118	Probable	Only vancomycin discontinuation	3	NA	NA
Govindarajan et al[44] (1999)	72	M	Epidural abscess	13	Probable	Trimethoprim/sulfmethoxazole	10	NA	NA
Kuruppu et al[45] (1999)	72	F	Endocarditis	14	Possible	Only vancomycin discontinuation	5	-	NA
Mizon et al[46] (1997)	71	F	Sepsis	< 10	Probable	Antibiotics withdrawn	4	+	+
Zenon et al[47] (1991)	54	M	Cellulitis	17	Probable	Antibiotics withdrawn	7	NA	NA
Christie et al[48] (1990)	73	F	Pneumonia	14	Probable	Platelet transfusion	2	+	NA
Christie et al[48] (1990)	31	M	Fever	< 10	Possible	Platelet transfusion	11 (not continued)	+	NA
Carmichael et al[49] (1986)	42	F	Endocarditis	82	Possible	NA	9	NA	NA

¹The lowest value during the vancomycin treatment.

²The time from vancomycin discontinuation to the resolution of vancomycin-induced thrombocytopenia. +: A positive result; -: A negative result. F: Female; M: Male; NA: Not available or not tested.