Copyright
©The Author(s) 2021.
World J Clin Cases. Mar 6, 2021; 9(7): 1619-1630
Published online Mar 6, 2021. doi: 10.12998/wjcc.v9.i7.1619
Published online Mar 6, 2021. doi: 10.12998/wjcc.v9.i7.1619
Table 1 Clinical features of the study population
Feature | CHB, n = 64 | Healthy donors, n = 37 | |||||
Treatment naïve, n = 52 | ETV treated, n = 12 | P1 value | Healthy adults, n = 24 | Healthy children, n = 13 | P2 value | P3 value | |
Age in yr | 43.23 ± 11.15 | 42.42 ± 11.27 | 0.821 | 45.58 ± 11.29 | 4.85 ± 3.71 | < 0.001 | 0.397 |
Sex, male, as n (%) | 37 (71.15) | 7 (58.33) | 0.388 | 15 (62.50) | 9 (69.23) | 0.682 | 0.451 |
ALT in U/L | 303.61 ± 511.12 | 28.09 ± 12.51 | < 0.001 | 38.77 ± 9.48 | 13.05 ± 4.28 | < 0.001 | < 0.001 |
AST in U/L | 176.37 ± 269.94 | 27.37 ± 24.17 | < 0.001 | 26.98 ± 7.12 | 32.88 ± 8.63 | 0.057 | < 0.001 |
GGT in U/L | 136.863 ± 274.897 | 33.700 ± 33.330 | 0.002 | 24.059 ± 24.006 | 9.462 ± 2.218 | 0.303 | < 0.001 |
ALP in U/L | 91.877 ± 33.706 | 66.320 ± 16.710 | 0.006 | 68.109 ± 21.576 | 249.692 ± 61.245 | 0.003 | 0.002 |
TBIL in μmol/L | 46.09 ± 88.60 | 16.78 ± 10.85 | 0.294 | 13.45 ± 5.91 | 5.91 ± 3.63 | 0.002 | 0.047 |
BUN in mmol/L | 5.70 ± 1.84 | - | - | 5.46 ± 1.45 | 3.94 ± 0.68 | < 0.001 | 0.764 |
SCr in μmol/L | 66.50 ± 19.72 | - | - | 57.36 ± 13.08 | 29.47 ± 11.08 | < 0.001 | 0.042 |
HBsAg in IU/mL | 10921.33 ± 17128.93 | 4024.78 ± 3602.66 | 0.460 | - | - | - | - |
HBV DNA as log10 IU/mL | 5.74 ± 1.98 | 1.28 ± 0.68 | < 0.001 | - | - | - | - |
HBeAg, positive, as n (%) | 29 (55.77) | 5 (41.67) | 0.378 | - | - | - | - |
TC in mmol/L | 4.055 ± 1.100 | - | - | - | - | - | - |
TG in mmol/L | 1.40 ± 0.84 | - | - | - | - | - | - |
HDL in mmol/L | 1.26 ± 0.52 | - | - | - | - | - | - |
LDL in mmol/L | 2.38 ± 0.79 | - | - | - | - | - | - |
IFNα in pg/mL | 60.60 ± 39.43 | 75.23 ± 33.69 | 0.115 | - | - | - | - |
IFNγ in pg/mL | 18.25 ± 19.46 | 15.86 ± 7.56 | 0.389 | - | - | - | - |
IL-12 in pg/mL | 13.80 ± 11.01 | 15.97 ± 7.01 | 0.247 | - | - | - | - |
IP-10 in pg/mL | 3523.89 ± 3095.67 | 892.17 ± 4396.24 | 0.001 | - | - | - | - |
TNFα in pg/mL | 40.68 ± 19.13 | 26.08 ± 11.41 | 0.005 | - | - | - | - |
Table 2 Correlation between clinical features and the level of soluble 4-1BB
s4-1BB | ||
r | P value | |
HBsAg in IU/mL | 0.748 | < 0.001 |
HBV DNA as log10 IU/mL | 0.406 | 0.004 |
HBeAg in s/co | 0.356 | 0.019 |
ALT in U/L | 0.234 | 0.102 |
AST in U/L | 0.165 | 0.246 |
GGT in U/L | 0.076 | 0.595 |
ALP in U/L | -0.065 | 0.651 |
TBIL in µmol/L | 0.063 | 0.662 |
BUN in mmol/L | -0.075 | 0.623 |
SCr in µmol/L | -0.226 | 0.135 |
WBC as × 109/L | -0.171 | 0.229 |
HGB in g/L | -0.063 | 0.662 |
PLT as × 109/L | -0.150 | 0.293 |
INR | 0.344 | 0.014 |
PTA, % | -0.353 | 0.012 |
FBG in mmol/L | -0.002 | 0.988 |
TC in mmol/L | -0.350 | 0.050 |
TG in mmol/L | -0.469 | 0.007 |
HDL in mmol/L | 0.148 | 0.481 |
LDL in mmol/L | -0.360 | 0.077 |
IFNα in pg/mL | -0.282 | 0.146 |
IFNγ in pg/mL | -0.314 | 0.104 |
IL-12 in pg/mL | -0.076 | 0.702 |
IP-10 in pg/mL | 0.154 | 0.434 |
TNFα in pg/mL | -0.031 | 0.874 |
- Citation: Zhan MR, Gao XZ, Wang C, Peng F, Wang XM, Xu HQ, Niu JQ. Elevated soluble 4-1BB is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B. World J Clin Cases 2021; 9(7): 1619-1630
- URL: https://www.wjgnet.com/2307-8960/full/v9/i7/1619.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v9.i7.1619