Dynamic monitoring of serum liver function indexes in patients with COVID-19

Table 1 Characteristics of the patients

No.	Sex	Age	Severity of diseases	Symptoms	Comorbidities	CT characteristic	AST at baseline, U/L	ALT at baseline, U/L
1	M	69	2	Fever, cough	DM, COPD	Interstitial changes	31	31
2	F	66	2	Fever, cough	DM	Interstitial changes	22	38
3	F	12	1	Sore throat	-		27	19
4	M	28	1	Sore throat	-		26	30
5	M	53	2	Fever, cough	HBP	Interstitial changes	10	19
6	M	58	3	Fever, cough	-	Interstitial changes	23	37
7	F	47	2	Sore throat	-	Interstitial changes	32	31
8	M	31	1	Fever, cough	-		10	14
9	F	37	2	Fever, cough	-	GGO	17	22
10	M	37	1	Sore throat	-	GGO	23	22
11	F	33	2	Fever, cough	DM	Interstitial changes	28	25
12	M	14	2	Sore throat	-	Interstitial changes	52	28

ALT: Alanine transaminase; AST: Aspartate transaminase; COPD: Chronic obstructive pulmonary disease; CT: Computed tomography; DM: Diabetes mellitus; GGO: Ground-glass opacity; HBP: High blood pressure.

Table 2 Liver function indexes

Indexes	Control group	Disease group
		Day 1	Day 3	Day 7	Day 14	P value
Albumin in g/L	40.42 ± 2.06	42.22 ± 3.99	36.59 ± 5.2a	31.80 ± 3.83b	36.98 ± 5.08a	< 0.001
TBIL in µmol/L	14.97 ± 6.54	11.38 ± 5.53	19.19 ± 6.25b	14.55 ± 3.68	12.00 ± 3.22c	0.025
DBIL in µmol/L	2.62 ± 0.72	2.44 ± 0.90	3.24 ± 1.10	3.15 ± 1.80	2.42 ± 0.76	0.199
ALT in U/L	27.22 ± 13.16	24.08 ± 11.46	21.82 ± 12.00	24.29 ± 20.06	32.00 ± 23.46	0.753
AST in U/L	23.21 ± 8.59	26.50 ± 7.28	25.36 ± 4.38	27.14 ± 19.36	25.80 ± 7.66	0.954
GGT in U/L	33.23 ± 14.95	28.17 ± 18.70	27.00 ± 16.95	25.29 ± 12.68	33.23 ± 14.95	0.682

^aP < 0.01 vs day 1.

^bP < 0.001 vs day 1.

^cP < 0.01 vs day 3. ALT: Alanine transaminase; AST: Aspartate transaminase; DBIL: Direct bilirubin; GGT: γ-glutamyltransferase; TBIL: Total bilirubin.