Regulation of the expression of proinflammatory cytokines induced by SARS-CoV-2

Table 1 Characteristics of KMT3 and KMT7 (based on the entries in www.uniprot.com, retrieved on August 21, 2020)

Category	Name of modifying enzymes	Other names	Targeting residue on histones	Effects
KMT3	3A	SETD2, SET2	Trimethylates H3K36	Transcription activation
	3B	NSD1	Methylates H3K36 or H4K20	Same as above
	3C	SMYD2	Monmethylates H3K4 or H3K36, monomethylates RB1 lys860	Same as above
	3D	SMYD1	Mono-, di- and trimethylates histone H3 K4'	Transcriptional repression
	3E	SMYD3	Di- and trimethylates H3K4, also methylates H4K5	Transcriptional activation
KMT6	KMT6	EZH2	Methylates H3K9 and H3K27	Transcription repression
KMT7	KMT7	SET7/9	Monomethylates histone H3K4	Transcriptional activation