New indicators in evaluation of hemolysis, elevated liver enzymes, and low platelet syndrome: A case-control study

Table 1 Comparisons of demographic and clinical features among the three groups

	HELLP①	Controls②	PE③	H/z/χ2	P value
Age in yr	30 (27, 34)	29 (27, 33)	30 (27, 33)	1.3781	0.502
Parity > 1	90/210	94/210	88/210	0.3623	0.834
Assisted reproduction	43/210	33/210	48/210	3.5143	0.173
Multiple pregnancies	29/210	15/210	23/210	4.9443	0.084
GA at delivery in wk	33.6 (31, 36.3)	39.3 (38.9, 39.7)	36.4 (33.8, 38.2)	313.1021	0.000b
				①:②-305.8432	0.000d
				①:③-90.4942	0.000d
				②:③215.3792	0.000d
Neonatal birthweight in g	1800 (1200, 2350)	3350 (3100, 3650)	2500 (1889, 3050)	291.9171	0.000b
				①:③-297.0862	0.000d
				①:③95.0862	0.000d
				②:③202.0002	0.000d

¹Indicates Kruskal-Wallis test with ^aP < 0.05, ^bP < 0.01.

²Indicates Bonferroni test with ^cP < 0.05, ^dP < 0.01.

³Indicates Chi-square test of R × C contingency table with ^eP < 0.05, ^fP < 0.01.

GA: Gestational age (noted as the number of weeks, and days were converted to weeks by calculation and showed in decimal form); HELLP: Hemolysis, elevated liver enzymes, and low platelet syndrome; PE: Preeclampsia.

Table 2 Indicators comparison among the complete blood count of three groups

	HELLP①	Controls②	PE③	H/z/χ2	P value
GA at CBC collection in wk	33.3 (30.3, 35.9)	39.1 (38.7, 39.7)	36.0 (33.0, 37.6)	310.4931	0.000b
				①:②-310.1402	0.000d
				①:③-76.8812	0.000d
				②:③224.2602	0.000d
NLR	6.4 (4.4, 9.8)	3.5 (2.8, 5.1)	4.3 (3.1, 6.4)	95.2791	0.000b
				①: ②171.6812	0.000d
				①:③106.6482	0.000d
				②:③-65.0332	0.001d
PLR	43.4 (28.1, 61.9)	103.6 (85.7, 129.7)	112.8 (83.3, 147.4)	312.2171	0.000b
				①:②-262.6692	0.000d
				①:③-280.1022	0.000d
				②:③-17.4332	0.979
Leukocyte count as 109/L	12.4 (9.2, 15.7)	8.7 (7.1, 11.4)	9.7 (7.9, 12.4)	73.3421	0.000b
				①: ②150.3952	0.000d
				①:③94.9552	0.000d
				②:③-55.4402	0.000d
Neutrophil count as 109/L	9.9 (7.1, 13.3)	6.1 (4.8, 8.7)	7.3 (5.6, 9.8)	81.8101	0.000b
				①: ②163.4332	0.000d
				①:③104.2672	0.000d
				②:③-59.1672	0.003d
Lymphocyte count as 109/L	1.4 (1.1, 2.0)	1.7 (1.4, 2.0)	1.6 (1.3, 2.0)	18.1531	0.000b
				①: ②-74.5382	0.000d
				①:③-48.5902	0.019c
				②:③25.9482	0.432
Platelet as 109/L	64.0 (49.0, 80.0)	180.5 (152.8, 211.3)	181.5 (146.0, 227.3)	401.0591	0.000b
				①:②-305.8212	0.000d
				①:③-310.2362	0.000d
				②:③-4.4142	1.000
Hemoglobin in g/L	104.0 (89.0, 118.0)	115.0 (107.0, 122.0)	116.5 (107.0, 125.0)	54.2861	0.000b
				①:②-104.1452	0.000d
				①:③-120.6622	0.000d
				②: ③-16.5172	1.000
Erythrocyte count	3.5 (3.0, 3.9)	3.8 (3.6, 4.0)	3.9 (3.7, 4.2)	67.7931	0.000b
				①:②-100.4672	0.000d
				①:③-142.1982	0.000d
				②: ③-41.7312	0.056
RDW as %	14.5 (13.6, 15.3)	14.1 (13.5, 14.8)	13.9 (13.4, 14.9)	11.0031	0.000b
				①:②45.7672	0.029c
				①: ③54.8992	0.006d
				②: ③9.1332	1.000
MPV in fL	11.9 (11.2, 12.9)	10.7 (10.2, 11.5)	11.2 (10.4, 12.1)	84.1461	0.000b
				①: ②160.7982	0.000d
				①: ③102.8672	0.000d
				②: ③-57.9312	0.003d
PDW in fL	16.4 (14.3, 18.8)	13.3 (11.9, 15.4)	14.2 (12.4, 16.2)	98.0521	0.000b
				①: ②170.3952	0.000d
				①: ③122.9192	0.000d
				②:③-47.476	0.023c

¹Indicates Kruskal-Wallis test with ^aP < 0.05, ^bP < 0.01.

²Indicates Bonferroni test with ^cP < 0.05, ^dP < 0.01.

CBC: Complete blood count; GA: Gestational age; HELLP: Hemolysis, elevated liver enzymes, and low platelet; MPV: Mean platelet volume; NLR: Neutrophil-to-lymphocyte ratio; PDW: Platelet distribution width; PE: Preeclampsia; PLR: Platelet-to-lymphocyte ratio; RDW: Red cell distribution width.