Negative conversion of autoantibody profile in chronic hepatitis B: A case report

Table 1 Laboratory values on admission and during hospital course

Parameters	Day 1	Day 7	Day 15	Day 25	2 mo	Reference ranges
WBC (× 109/L)	3.05	4.18	4.93	3.76	556	3.5-9.5
PLT (× 109/L)	101	93	102	112	216	125-350
AST (U/L)	593	224	75	28	34	0-34
ALT (U/L)	575	266	89	26	28	0-49
ALP (U/L)	112	132	116	79	76	45-129
GGT (U/L)	58	134	113	55	36	0-38
LDH (U/L)	267	208	159	159	221	120-246
ALB (g/L)	34.8	34.3	28.9	33.7	27.8	35.0-53.0
TBIL (μmol/L)	38.30	45.90	108.30	51.45	11.30	5.00-21.00
DBIL (μmol/L)	22.50	33.20	84.92	37.37	8.09	0-6.80
HBV-DNA (copies/mL)	7.21 × 108			1.62 × 104	≤ 500	≤ 500
HBsAg (IU/mL)	> 52000			3373	135	< 0.05
ANA	< 1:80			< 1:80	< 1:80	Negative (< 1:80)
Anti-SM (RU/mL)	41.17			< 20	< 20	< 20
Anti-SS-A (RU/mL)	42.70			< 20	< 20	< 20
Anti-SS-B (RU/mL)	176.31			< 20	< 20	< 20
CENTRO (RU/mL)	39.59			< 20	< 20	< 20
AMA-M2 (RU/mL)	19.99	25.87		< 20	< 20	< 20
LKM-1 (RU/mL)	223.38	> 400		< 20	< 20	< 20
SLA/LP (RU/mL)	39.61	43.04		< 20	< 20	< 20
SP100 (RU/mL)	16.26	20.59		< 20	< 20	< 20
Anti-HCV	Negative			Negative	Negative	Negative
HAV-IgM	Negative			Negative	Negative	Negative
HEV-IgM	Negative			Negative	Negative	Negative
Anti-HIV	Negative			Negative	Negative	Negative

ALB: Albumin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AMA-M2: Anti-mitochondrial antibody subtype ІІ; AST: Aspartate transaminase; CENTRO: Anti-centromere B antibody; DBIL: Direct bilirubin; GGT: Glutamyltransferase; HAV: Hepatitis A virus; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; HCV: Hepatitis C virus; HEV: Hepatitis E virus; LDH: Lactate dehydrogenase; LKM-1: Anti-liver/kidney microsomal-1 antibody; SLA/LP: Anti-soluble liver antigen/liver-pancreas; SP100: Anti-SP100 antibody; TBIL: Total bilirubin; WBC: White blood cell.