Case Report
Copyright ©The Author(s) 2021.
World J Clin Cases. Feb 16, 2021; 9(5): 1156-1167
Published online Feb 16, 2021. doi: 10.12998/wjcc.v9.i5.1156
Table 1 Clinical characteristics of published cases of secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome in adults
Order
Diagnosis
Case number
Age/Gender
Duration from MDS to PAP
Treatment
Anti-GM-CSF Ab
Concomitant disease
Chromosomal abnormality
Genetic abnormality
Survival time after PAP
Outcome
Survival time after MDS
Ref.
1MDS139/M1 yr after MDSNANAPulmonary fungusNANAShortlyDied1 yr[21]
2MDS165/FCoincidenceMethylprednisolone and GM-CSFNANoneNANAShortlyDiedShortly[21]
3RA deteriorated into AL after 2 yr127/M1 yr after ALAntibiotics and anti-tuberculosis agentsNANoneNANA4 moDied3 yr[10]
4RA deteriorated into AL after 1 yr165/F1 mo after ALFluconazole and miconazoleNAPulmonary fungusNANA1 moDied1 yr[10]
5RAEB-T152/F2 yr after RAEB-TAmphotericin BNAPulmonary fungusNANA4 moDied1 yr[10]
6RA deteriorated into AL within 1 yr170/M1 yr after ALChemotherapyNAMalignant melanomaNANA4 moDied2 yr[10]
7RA deteriorated into RAEB after 12 yr150/MCoincidence with RAEBPrednisoloneNegativeHypereosinophil46, XY, -1,-14,+2mar[1] and 46, XY[3] at first diagnosis and 47, XY, add (1)(p11), +add(1), t(1;19)(q11;q11), -14, +mar at disease progressionNA2 yrAlive14 yr[22]
8MDS166/M12.5 yrPrednisolone and amobroxolNegativeNA47, XY, add(1)(p11), +add(1),t(1;19)(p10; q10), –14, +mar1[20/20]NANANANA[23]
9MDS147/M2 yrNANegativeNANANAShortlyDied2 yr[24]
10MDS-RA deteriorated into RAEB after 9 yr136/M1 yr after RAEBCord blood transplantation and GM-CSFNegativeNoneNANA1 yrAlive11 yr[25]
11MDS139/FNABALNANANANANAAliveNA[8]
12MDS-RA deteriorated into RAEB after 1 yr148/M1 yr with RAEBWLLNegativeNone47, XY, +8NA2 rAlive3 yr[26]
13RCMD141/F3 yrPrednisolone and antibioticsNANone46, XX, –20; der (20)del (20)(q11q13) idic(20) (p11), or idic(20q–)NA7 moDied4 yr[4]
14MDS-RA134/M1 yrUnrelated bone marrow transplantationNegativeIBD47, XY, +8NA1 yrAlive3 yr[27]
15MDS-RAEB142/F4 mo before RAEBUnrelated cord blood transplantation.NegativeIBD47, XX, +8NA4 moDiedShortly[27]
16MDS-RAEB152/F8 yr before RAEBUnrelated bone marrow transplantationNegativeBD and IBD47, XX, +8NA10 yrAlive2 yr[27]
17MDS134/M2 yr before MDSBALNANANANANANANA[17]
18MDS-MLD138/MNANANegativeNANANANADied< 2 yr[15]
19MDS-SLD126/MNANANegativeNANANANADied< 2 yr[15]
20MDS-U137/MNANANegativeNANANANADied< 2 yr[15]
21MDS-EB133/MNANANegativeNANANANADied< 2 yr[15]
22Very low + low MDS13Age: 45 (30-67); Gender: 7 M/6 FMDS to sPAP: 0 to 168 mo 2 case beforeNANegativeNAGood: 2; Intermediate: 11NA13 mo7 Died; 6 AliveNA[5]
34Inter-high + very high18Age: 50 (27-57); Gender: 12 M/6 FMDS to sPAP: 0 to 228 mo 6 cases beforeNANegativeNAIntermediate: 13; Poor: 5NA15 mo10 Died; 8 AliveNA[5]
51MDS-U deteriorated into RCMD after 11 mo and deteriorated into RAEB-1 after 13 mo175/FCoincidence with RAEB1PrednisoloneNegativeOrganizing pneumoniaNormal karyotypeNA6 moDied19 mo[16]
52MDS-RA146/F3 yrSteroid pulse, cyclosporine A and infliximabNABD and myelofibrosisTrisomy 8NA30 moDied66 mo[28]
53MDS-RA131/M2 yrSteroidNABDTrisomy 8NA2 moDied2 yr[28]
54MDS-RAEB2150/FCoincidence with RAEBWLLNABDTrisomy 8NA2 yrAlive2 yr[28]
55MDS140/MNAStem cell transplantationNANANANANAAliveNA[19]
56MDS151/FNANANegativeLGL, metastatic melanoma, DVTNormal karyotypeGATA2NADied12 yr[29]
57MDS/AML133/MLess than 1 yrNANegativeNone-7GATA2< 1 yrDied< 1 yr[29]
58MDS126/FLess than 1 yrNANegativeHypothyroidismNormal karyotypeGATA2< 1 yrDied< 1 yr[29]
59MDS126/FNANANegativeLGL, breast cancer, miscarriageNormal karyotypeGATA2NADied27 yr[29]
60MDS/AML119/FNANANegativeLGL/DVTNormal karyotypeGATA2NADied25 yr[29]
61MDS128/MNANANegativeNoneTrisomy 8GATA2NAAlive6 yr[29]
62MDS118/FNANANegativeLGL, miscarriageNormal karyotypeGATA2NADied31 yr[29]
63CMML148/FNANANegativeLGL, HT, Pancreatic cancerNormal karyotypeGATA2NADied11 yr[29]
64MDS159/FVery soonNANegativeNANAGATA2ShortlyDiedShortly[30]
65CMML163/MCoincidence with CMML-1ChemotherapyNANoneinv(6)JAK2-V617F5 yrDied5 yrCurrent study