Neuropathy and chloracne induced by 3,5,6-trichloropyridin-2-ol sodium: Report of three cases

Table 1 List of clinical symptoms of the three patients

Characteristics	Patient 1	Patient 2	Patient 3
Sex	Male	Male	Male
Age	29	33	26
Manifestation of the skin eruptions	Grey-black changes on the face, intensive distribution of yellow to brownish, miliary to mung bean-sized papules and nodules were seen over the head, face, neck, torso, armpit, lower limb, hips, and perineum; some lesions were covered with pus plugs and blackheads; some lesions were fused	Intensive distribution of yellow to brownish, miliary to mung bean-sized papules and nodules were seen over the head and face; some lesions were covered with pus plugs and blackheads; similar lesions were distributed discretely over the other body parts	Intensive distribution of yellow to brownish, miliary to mung bean-sized papules and nodules over the face, neck, and chest were observed; some lesions were covered with pus plugs and blackheads; similar lesions were distributed discretely over the other body parts
Time to skin lesion	3 d	1 wk	2 wk
Neurological damages	Bilateral calf pain	None	Bilateral calf pain
Ocular symptoms	Increased eye secretions with itching, and difficulty to keep eye open	None	None
Gastrointestinal symptoms	Nausea, but no abdominal pain, diarrhea, or vomiting	None	None
Liver function	ALT 20105.30 U/L, AST 8074.50 U/L (significantly increased AST)	ALT 45.30 U/L, AST 38.80 U/L (normal)	ALT 23453.40 U/L, AST 9735.23 U/L (significantly increased AST)
Routine blood test	WBC 23.20 × 109/L, NE% 93.80%	Normal	WBC 21.40 × 109/L, NE% 89.70%
Liver function (3 mo later)	ALT 22.70 U/L, AST 28.50 U/L	ALT 31.10 U/L, AST 20.80 U/L	ALT 35.20 U/L, AST 54.90 U/L
Routine blood test (3 mo later)	WBC 8.58 × 109/L, NE% 78.74%	WBC 7.22 × 109/L	WBC 9.43 × 109/L
Treatments	Valentate, mecobalamin, oral mediaction with diclofenac sodium and codeine phosphate tablet, and topical use of adapalene gel	Valentate, mecobalamin, oral mediaction with diclofenac sodium and codeine phosphate tablet, and topical use of adapalene gel	Valentate, mecobalamin, oral mediaction with diclofenac sodium and codeine phosphate tablet, and topical use of adapalene gel
Current status (1 yr later)	Newly occurring rashes are still seen intermittently on the neck	Skin eruptions on the face have subsided at present	Skin eruptions on the face have subsided at present

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; WBC: White blood cells; NE: Neutrophils.