Ninety-four thousand-case retrospective study on antibacterial drug resistance of Helicobacter pylori

Table 1 Basic information of specimen tested for H. pylori infection (n)

Age group	Infection rate (%)	Tested specimen			H. pylori–positive specimen			Multivariable analysis
		Total	Male	Female	Total	Male	Female	OR	95%CIa	P value
Total	33.30	283823	142851	140972	94509	49139	45370	-	-	-
≤ 20	22.49	4825	2576	2249	1085	624	461	1.240	1.082 1.421	0.002
21-30	26.78	21681	11655	10026	5807	3196	2611	1.073	1.010 1.140	0.022
31-40	27.24	46803	23720	23083	12750	6688	6062	1.103	1.059 1.148	0.000
41-50	29.76	80907	39271	41636	24078	12156	11922	1.117	1.084 1.152	0.000
51-60	38.86	72229	35077	37152	28066	14284	13782	1.165	1.131 1.200	0.000
61-70	43.33	40951	21065	19886	17744	9250	8494	1.050	1.010 1.092	0.014
71-80	32.39	13939	7866	6073	4515	2635	1880	1.123	1.046 1.207	0.001
≥ 81	18.65	2488	1621	867	464	306	158	1.044	0.844 1.292	0.690

^a95%confidence interval (lower bound, upper bound).

CI: Confidence interval; H. pylori: Helicobacter pylori.

Table 2 The multiple-drug resistance of H. pylori to the four antibacterial drugs, n

Antibacterial drugs	Total	Male	Female
Sensitivea	4314	2485	1829
LEV	626	362	264
CLA	557	332	225
MTR	50413	26642	23771
AMX	0	0	0
LEV + CLA	444	234	210
LEV + MTR	16419	8343	8076
LEV + AMX	1	1	0
CLA + MTR	10551	5599	4952
CLA + AMX	0	0	0
MTR + AMX	17	14	3
LEV + CLA + MTR	10990	5035	5955
LEV + CLA + AMX	0	0	0
LEV + MTR + AMX	48	25	23
CLA + MTR + AMX	28	16	12
LEV + CLA + MTR + AMX	101	51	50

^aSensitive to all four antibacterial drugs. CLA: Clarithromycin; LEV: Levofloxacin; MTR: Metronidazole; AMX: Amoxicillin.