Blood tests for prediction of deep endometriosis: A case-control study

Table 1 Baseline clinical characteristics and serum lipid profiles of participants

Variable	Control group (n = 95)	DE (n = 31)	P value
Age (yr), mean ± SD	31.57 ± 5.03	32.10 ± 5.13	0.61
BMI (kg/m2), mean ± SD	21.37 ± 2.67	20.36 ± 2.17	0.06
Parity, n (%)			0.41
0	35 (71.43)	14 (28.57)
≥ 1	60 (77.92)	17 (22.08)
Abortion, n (%)			0.90
0	50 (75.76)	16 (24.24)
1	18 (72.00)	7 (28.00)
≥ 2	27 (77.14)	8 (22.86)
TG (mmol/L), median (Q1-Q3)	0.80 (0.64-1.12)	0.81 (0.57-0.99)	0.33
TC (mmol/L), median (Q1-Q3)	4.27 (3.80-4.82)	4.09 (3.80-4.77)	0.80
HDL (mmol/L), median (Q1-Q3)	1.32 (1.14-1.59)	1.39 (1.19-1.55)	0.70
LDL (mmol/L), median (Q1-Q3)	2.16 (1.83-2.60)	2.16 (1.81-2.69)	0.98

Data are mean ± SD for normally distributed variables, medians (Q1-Q3) for variables without a normal distribution, and n (%) for categories variables. BMI: Body mass index, DE: Deep endometriosis; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; TC: Total cholesterol; TG: Total triglycerides.

Table 2 Hemostatic parameters and inflammation indices of participants with or without deep endometriosis

Variable	Controls (n = 95)	DE (n = 31)	P value
PT (s)	12.91 ± 0.61	13.11 ± 0.59	0.11
INR	1.01 (0.98-1.04)	1.05 (1.00-1.07)	0.03
APTT (s)	36.11 ± 3.16	36.84 ± 3.18	0.27
TT (s)	15.56 ± 0.61	15.29 ± 0.56	0.03
Fg (g/L)	2.83 (2.53-3.14)	3.09 (2.73-3.97)	0.01
PLT (109/L)	228.00 (185.00-258.00)	235.00 (212.00-262.00)	0.32
HB (g/L)	130.00 (124.00-136.00)	126.00 (115.00-130.00)	0.02
WN (109/L)	3.90 (3.00-4.80)	3.30 (2.80-4.10)	0.27
WL (109/L)	1.65 (1.30-2.00)	1.60 (1.30-1.80)	0.34
MPV (fL)	8.60 (7.90-9.70)	8.40 (7.80-8.90)	0.23
PCT (%)	0.19 (0.17-0.22)	0.20 (0.18-0.23)	0.21
NLR	2.16 (1.59-3.20)	2.31 (1.58-2.78)	0.86
PLR	130.00 (108.82-180.00)	154.71 (128.95-179.09)	0.08
CRP (mg/L)	12.91 ± 0.61	13.11 ± 0.59	0.01

Data are mean ± SD for normally distributed variables and medians (Q1-Q3) for abnormal variables without a normal distribution. APTT: Activated partial thromboplastin time; CRP: C-reactive protein Fg: Fibrinogen; HB: Hemoglobin; INR: International standardized ratio; MPV: Mean platelet volume; NLR: Neutrophil-to-lymphocyte ratio; PCT: Platelet distribution width; PLR: Platelet-to-lymphocyte ratio; PLT: Platelet count; PT: Prothrombin time; TT: Thrombin time; WL: Lymphocyte number; WN: Neutrophil number.

Table 3 Unadjusted association of hemostatic parameters and inflammation indices with deep endometriosis by logistical regression

Variables	β (SE)	P value	OR (95%CI)
PT	0.49 (0.19)	0.01	1.63 (1.12, 2.38)
Fg	0.51 (0.20)	0.01	1.67 (1.13, 2.46)
TT	−0.38 (0.19)	0.04	0.69 (0.48, 0.99)
PLT	0.23 (0.19)	0.24	1.26 (0.86, 1.83)
HB	−0.47 (0.20)	0.02	0.63 (0.42, 0.92)
WN	−0.22 (0.19)	0.25	0.81 (0.56, 1.16)
WL	−0.17 (0.19)	0.37	0.85 (0.59, 1.22)
MPV	−0.22 (0.18)	0.24	0.81 (0.56, 1.15)
PCT	0.24 (0.18)	0.18	1.27 (0.89, 1.8)
CRP	−0.19 (0.20)	0.34	0.82 (0.55, 1.22)

CI: Confidence interval; CRP: C-reactive protein; Fg: Fibrinogen; HB: Hemoglobin; MPV: Mean platelet volume; OR: Odds ratio; PCT: Platelet distribution width; PLT: Platelet count; PT: Prothrombin time; SE: Standard error; TT: Thrombin time; WL: Lymphocyte number; WN: Neutrophil number.

Table 4 Stepwise logistical regression analysis and receiver operating characteristic analysis for deep endometriosis, hemostatic parameters, and inflammatory indices

Variable	OR (95%CI)	Sensitivity	Specificity	AUC (95%CI)	Cutoff value
Fg	2.12 (1.31, 3.75)a	0.581	0.705	0.639 (0.524, 0.755)a	3.04
HB	0.48 (0.29, 0.78)a	0.645	0.621	0.664 (0.552, 0.776)a	128
Fg + HB	-	0.677	0.789	0.773 (0.677, 0.868)a	3.09 + 126

^aP < 0.05. Age, BMI, history of delivery and abortion, and serum lipid profiles were entered into the stepwise regression model with SLE = 0.05, SLS = 0.10. AUC: Area under the curve; CI: Confidence interval; Fg: Fibrinogen; HB: Hemoglobin; OR: Odds ratio.