Application of traditional Chinese medicine in treatment of Helicobacter pylori infection

Table 1 Recommended scheme for traditional Chinese medicine syndrome differentiation and typing

Syndrome	Treatment	Main prescription	Medicament
Dampness-heat syndrome in spleen and stomach (heat)	Clearing heat and dampness, and regulating and neutralizing Qi	Coptis and Officinal Magnolia Bark Beverage	Magnolia officinalis, Coptis chinensis, Acorus tatarinowii, Rhizoma Pinelliae, Sojae Semen Praeparatum, Gardenia jasminoides Ellis, Phragmitis Rhizoma
		Xiaoyou Fuwei Decoction	Radix scutellariae, Coptis chinensis, Astragalus membranaceus, Atractylodes macrocephala, Rheum palmatum, Pinellia ternata, Wolfiporia cocos, Tetradium ruticarpum, Cynanchum otophyllum, Glycyrrhizae
		Jiawei Pingwei powder	Bupleurum chinense, Atractylodes macrocephala, Atractylodes Lancea, Magnolia officinalis, Coptis chinensis, Costusroot, Rhizoma corydalis, Sepia esculenta
		Yiwei Zhitong Kangyou decoction	Taraxacum mongolicum, Gardenia jasminoides Ellis, Coptis chinensis, Liliumbrownii var. viridulum, Aurantii Fructus, Lindera aggregata, Melia toosendan Sieb, Pogostemon cablin, Finger Citron, Faeces Trogopterpri, Rhizoma Cyperi, Typhae Pollen, Amomum
		Zuojin Decoction	Concha Arcae, Radix Astragali preparata, Coptis chinensis, Evodia, Calcined oyster, Rhizoma Cyperi, Bupleurum, curcuma, ginseng, Glycyrrhizae, pseudo-ginseng
Deficiency spleen and stomach (cold)	Strengthening spleen and replenishing qi, and easing stomach	Curative effect of Sijunzi decoction	Costusroot, Amomi fructus, Citrus, Rhizoma Pinelliae Preparatu, Radix codono-psis, Rhizoma Atractylodes, Poria cocos, Glycyrrhizae
		Shenqi Yangwei decoction	Radix Astragali, Semen Coicis, Codonopsis pilosula, Paeonia lactiflora Pall, Pinellia ternata, Scutellaria baicalensis, Bletilla striata, CassiaTwig, Atractylodes, rhizoma corydalis, Bupleurum, Curcuma zedoaria, Glycyrrhizae, Rheum palmatum L
		Zishengtang	Codonopsis pilosula, Atractylodes macrocephala, Wolfiporia cocos, Alisma plantago-aquatica, Dioscorea oppositifolia L, Semen Nelumbinis, Orange peel, Hordeurn vulgare L, Massa Medicata Fermentata, Semen Coicis, Euryale ferox Salisb, Amomum villosum Lour, DolichoslablabL, Crataegus pinnatifida, Platycodon grandiflorus, Agastache rugosa, AIpinia tonkinensis Gagnep, Coptis chinensis, Glycyrrhizae
Cold-heat complicated syndrome	Opening with acridity and decreasing bitter, and regulating stomach Qi and removing painful abdominal mass	Banxia Xiexin Decoction	Rhizoma Pinelliae, Scutellaria baicalensis Georgi, Coptis chinensis, Zingiber officinale Rosc, Glycyrrhizae, Codonopsis pilosula, Ziziphus jujuba Mill
		Zhishi Xiaopi decoction	Vaccaria segetalis, Hirudo, Rhizoma corydalis, Curcuma zedoaria, Citrus aurantium L, Sepia esculenta, Radix Aucklandiae, Atractylodes macrocephala, Cynanchum paniculatum, Hedyotisdiffusa, Magnolia officinalis, Pseudostellaria, Astragalus membranaceus

Table 2 Anti-Helicobacter pylori active ingredients in the recommended classification scheme

Main anti-H. pylori drugs	Active ingredients in anti-H. pylori drugs	Drug-resistant inhibitors	Drug-resistant Sensitizer	Synergies agent
Magnolia officinalis	Magnolol, honokiol	+	-	-
Coptis chinensis	Berberine, rhizome, epiberberine, palmatine, coptisine	+	+	+
Gardenia	geniposide	-	-	-
Radix scutellariae	Baicalin, baicalein, neobaicalein, norwogonin, skullcap flavone, acacetin, wogonin	+	+	+
Radix Astragalus	astragalus saponin	+	-	-
Rhubarb	Rhein, emodin	+	+	+
Evodia	Limonin, rutecarpine	+	-	-
Bupleurum	saikosaponin-d	+	-	-
Rhizoma corydalis	Quinolone alkaloids	-	-	-
Pogostemon cablin	Patchouli alcohol	+	-	-
Curcuma longa	Diterpenoid C extracted from radix curcumae, curcumin	+	-	-
Ginseng	Panaxotriol, ginsenoside	-	-	-
Pseudo-ginseng	Sanchinoside	-	-	-

+: Existing literature has shown this effect; -: No previous research reporting this effect; H. pylori: Helicobacter pylori.

Table 3 Anti-Helicobacter pylori program of combination of traditional Chinese and Western medicines

TCM syndrome-type	Treatment	Course of treatment and dose	Efficient rate
Dampness-heat syndrome in the spleen and stomach (heat)	Jiawei Pingwei powder combined with triple therapy (Rabeprazole + Clarithromycin + Amoxicillin)	Jiawei Pingwei powder (2 times/d) + Rabeprazole (10 mg, 2 times/d) + Clarithromycin (0.25 g, 2 times/d) + Amoxicillin (0.25 g, 2 times/d). Course of treatment: 14 d	The combined treatment: 93. 48%; Western medicine alone: 77. 55%
Deficiency spleen and stomach (cold)	Xiangsha Liujunzi decoction combined with antibiotic (Rabeprazole)	Xiangsha Liujunzi decoction (1 time /d) + Rabeprazole (10 mg, 2 times/d). Course: 14-28 d	The combined treatment: 96.67%; Western medicine alone: 80.00%
Cold-heat complicated syndrome	Banxia Xiexin secoction combined with antibiotics (Omeprazole + aluminum magnesium carbonate)	Banxia Xiexin decoction (2 times/d) + Omeprazole (10 mg, 2 times/d) + aluminum magnesium carbonate (0.5 g, 3 times/d). Course: 14-28 d	The combined treatment: 96.00%; Western medicine alone: 76.00%

TCM: Traditional Chinese medicine.