Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation, normal T-cell expressed and secreted

doi:10.12998/wjcc.v9.i34.10451

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Dec 6, 2021 (publication date) through Apr 23, 2024

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Dec 6, 2021; 9(34): 10451-10463
Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10451

Table 1 Serum regulated on activation, normal T-cell expressed and secreted, tumor necrosis factor α, interleukin 1β, and interleukin 6 levels in rats of different groups

Group	RANTES (ng/mL)	TNF-α (pg/mL)	IL-1β (pg/mL)	IL-6 (pg/mL)
Control (n = 11)	0.65 ± 0.25	124.91 ± 11.29	185.87 ± 24.97	183.69 ± 43.02
Model (n = 9)	5.17 ± 0.70^a	256.89 ± 19.55^a	383.01 ± 41.85^a	380.99 ± 44.11^a
LM (n = 9)	4.07 ± 0.67^a^,^b	167.39 ± 20.92^a^,^b	318.83 ± 74.06^a^,^b	308.21 ± 73.22^a^,^b
MM (n = 10)	3.13 ± 0.45^a^,^b^,^c	143.87 ± 15.22^a^,^b^,^c	256.79 ± 25.37^a^,^b^,^c	246.14 ± 41.73^a^,^b^,^c
HM (n = 10)	2.52 ± 0.28^a^,^b^,^c^,^d	144.49 ± 18.02^a^,^b^,^c	225.07 ± 17.46^a^,^b^,^c^,^d	215.18 ± 12.49^a^,^b^,^c^,^d

The contents of regulated on activation, normal T-cell expressed and secreted and cytokines in serum of septic rats after magnolol intervention were determined using enzyme-linked immunosorbent assay. All data are represented as the mean ± SD.

^aP < 0.01 vs Control group.

^bP < 0.05 vs Model group.

^cP < 0.05 vs LM group.

^dP < 0.05 vs MM group.

TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β; IL-6: Interleukin-6; RANTES: Regulated on activation, normal T-cell expressed and secreted; Control: The Control group; Model: Severe sepsis group; LM: Low-dose magnolol group; MM: Middle-dose magnolol group; HM: High-dose magnolol group.

Table 2 Ileal regulated on activation, normal T-cell expressed and secreted, tumor necrosis factor α, interleukin 1β, and interleukin 6 levels in rats of different groups

Group	RANTES (g/mL)	TNF-α (pg/mL)	IL-1β (pg/mL)	IL-6 (pg/mL)
Control (n = 11)	3.40 ± 1.45	347.04 ± 60.66	240.4 ± 37.08	195.11 ± 28.60
Model (n = 9)	29.29 ± 4.07^a	1015.73 ± 90.96^a	453.52 ± 54.82^a	436.01 ± 46.29
LM (n = 9)	22.47 ± 3.72^a^,^b	720.82 ± 88.16^b	330.89 ± 49.06^a^,^b	337.66 ± 73.79^b
MM (n = 10)	17.39 ± 2.59^a^,^b^,^c	487.48 ± 115.29^a^,^b	301.43 ± 44.51^a^,^b	271.25 ± 36.82^b^,^c
HM (n = 10)	14.10 ± 1.59^a^,^b^,^c^,^d	428.79 ± 48.71^a^,^b^,^c	294.27 ± 68.2^a^,^b	237.75 ± 16.05^b^,^c^,^d

The expression levels of regulated on activation, normal T-cell expressed and secreted and cytokines in ileal tissue of septic rats after magnolol intervention were determined using Western blot assay. All data are represented as the mean ± SD.

^aP < 0.01 vs Control group.

^bP < 0.05 vs Model group.

^cP < 0.05 vs LM group.

^dP < 0.05 vs MM group.

Citation: Mao SH, Feng DD, Wang X, Zhi YH, Lei S, Xing X, Jiang RL, Wu JN. Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation, normal T-cell expressed and secreted. World J Clin Cases 2021; 9(34): 10451-10463
URL: https://www.wjgnet.com/2307-8960/full/v9/i34/10451.htm
DOI: https://dx.doi.org/10.12998/wjcc.v9.i34.10451