Clinical considerations for critically ill COVID-19 cancer patients: A systematic review

Table 1 Study demographic details

Ref.	Country	Study type	Mean age (yr)	Gender	COVID-19 diagnosis	No. of patients	ICU admission rates1	Mortality rates1
Garassino et al[13] (TERAVOLT)	Multinational (8 countries)	Observational-cross sectional	68	M: 141 (70%); F: 59 (30%)	RT-PCR, or imaging	200	13 (9%)	33%
Passamonti et al[2]	Italy	Retrospective	66.8	M: 340 (63%); F: 196 (37%)	RT-PCR	536	82 (15%)	37%
García-Suárez et al[3]	Spain	Prospective observational cohort study	72	M: 413 (60%); F: 277 (40)	RT-PCR	697	55 (8%)	33%
Lee et al[8]	United Kingdom	Prospective- observational	69	M: 449 (56%); F:349 (44%)	RT -PCR	800	53 (7%)	28%
(UKCCMP)
Mato et al[9]	United States and Europe	Retrospective cohort	70.5	M: 125 (63%); F: 73 (37%)	RT-PCR	198	70 (35%)	33%
Fürstenau et al[5]	Europe and Israel	Randomized control trial	61	M: 4 (57%); F:3 (43%)	RT-PCR	7	2 (29%)	29%
He et al[4]	China	Case control study	35	M: 7 (56%); F: 6 (44%)	RT-PCR or imaging	13	NA	61%
Fattizzo et al[30]	Italy	Case series	77	M: 10 (63%); F: 6 (37%)	RT-PCR	16	2 (12%)	31%
de Joode et al[14]	Netherlands	Observational cohort study	70	M: 187 (53%); F: 164 (47%)	RT-PCR or imaging	351	NA	32%
Pinato et al[24]	Europe, United Kingdom, Italy, Spain	Retrospective observational	69.3	M: 127 (62%); F:77 (38%)	RT-PCR	204	36 (18%)	29%
Kuderer et al[6] (CCC19)	United States, Canada, Spain	Retrospective	66	M: 468 (50%); F: 460 (50%)	RT-PCR	928	132 (14%)	13%
Robilotti et al[21]	United Sates	Retrospective	NA	M: 212 (50%); F: 211 (50%)	RT-PCR	423	NA	12%
Ramaswamy et al[11]	India	Prospective observational	42	M: 124 (54%); F: 106 (46%)	RT-PCR	230	8 (3%)	10%
Nichetti et al[12]	Italy	Prospective observational	61	M: 4 (36%); F: 7 (64%)	RT-PCR	11	1 (9%)	55%
Kuderer et al[6]	Canada	Prospective observational	73	M: 127 (50%); F: 150 (50%)	RT-PCR	252	71 (28%)	13%
Lara et al[17]	United States	Retrospective	64	F: 121 (100%)	RT-PCR	121	20 (16%)	14%
Zhang et al[16]	China	Retrospective	66	M: 60 (56%); F: 47 (44%)	RT-PCR or imaging	107	NA	22%
Dai et al[15]	China	Case control study	64	M: 57 (55%); F: 48 (46%)	RT-PCR or imaging	105	20 (19%)	11%

¹Percentage in decimals were rounded to the nearest whole number. RT-PCR: Reverse transcriptase polymerase chain reaction; M: Male; F: Female; UKCCMP: The United Kingdom Coronavirus Cancer Monitoring Project; CCC19: Coronavirus disease 2019 and Cancer Consortium; COVID-19: Coronavirus disease 2019; ICU: Intensive care unit; NA: Not available.