Case Report
Copyright ©The Author(s) 2021.
World J Clin Cases. Sep 6, 2021; 9(25): 7593-7599
Published online Sep 6, 2021. doi: 10.12998/wjcc.v9.i25.7593
Table 1 Infliximab-associated pericardial complications reported in the literature including the present case
Cases
Age (yr)
Gender
Primary disease
Pericardial complications
Clinical presentation
Duration of IFX Treatment
Follow-up treatment
Outcome
168FemaleRATransudate, constrictiveRight heart failure: leg edema and anorexia40 dInfliximab discontinuation, pericardiocentesisPericardial effusion not increased
257FemaleRAHemorrhagicShortness of breath, right heart failure14 moPericardiocentesisRecurrent disease, pericardiectomy
370FemaleRAInfective pericarditisCardiac failure, fatigue, dyspnea6 yrStop etanercept, pericardiocentesis and pericardial drain, antibioticsWhite cell count normalized, CRP fallen
475FemaleRA-Dyspnea4 yrSteroidReadmitted with recurrent symptoms, pericardiocentesis
560FemaleRA-Cardiovascular collapse4 moPericardiocentesis, steroidClinical symptoms and pericardial effusion improved
645MaleRAHemorrhagic, DILEFever, cough, polyarthralgia, chest pain 22 wkInfliximab discontinuation, steroidClinical symptoms and pericardial effusion improved
757MaleRA PurulentCollapse3 wkPericardiocentesis, antibiotics, infliximab discontinuationFenestration for residual pericardial effusion
840MaleRA-Chest pain, chest discomfort15 moAntibiotics, steroidRecurrent disease, pericardiectomy
951FemaleUCDILEChest pain, shortness of breath, fatigue1 wkInfliximab discontinuation, steroid Clinical symptoms improved
1048FemaleUCCardiac tamponadeChest pain, dyspnea1 moInfliximab discontinuation, pericardiocentesis, diuresisNo recurrence or persistent cardiac dysfunction
1159MaleUCNon-infectiousLeft-sided chest pain1 moInfliximab discontinuation, NSAIDS, adalimumabNo recurrence of pericarditis
1260MaleUCHemorrhagic, cardiac tamponade Shortness of breath, diffuse joint swelling and aches, general malaise 1 wk (infliximab was reintroduced)Infliximab discontinuation, antibioticsProgressive shortness of breath and recumbent chest pain, pericardiocentesis, steroid and pericardial drain were performed, pericardial effusion decreased
1341MaleUCDILE, cardiac tamponadePleuritic chest pain, dyspnea19 moInfliximab discontinuation, steroidNo residual pericardial effusion
1430FemaleCDFibrinous, cardiac tamponadePleuritic chest pain, dyspnea12 moInfliximab discontinuation, pericardial window, mediastinal chest tube, steroidNo recurrence of symptoms of pericarditis
1557MaleCDPurulent, cardiac tamponadeChest pain, fever, general malaise 8 yrInfliximab discontinuation, pericardial window, antibioticsAsymptomatic
1639MaleCDDILEPleuritic chest pain, nausea, weakness8 moSteroidSevere arthralgia when used infliximab one more time; no recurrence of lupus-like symptoms after infliximab discontinuation
17127MaleCDHemorrhagicDyspnea, fever and worsening weakness7 wkInfliximab discontinuation, pericardiocentesisClinical symptoms and pericardial effusion improved