Meta-Analysis
Copyright ©The Author(s) 2021.
World J Clin Cases. Aug 26, 2021; 9(24): 7073-7084
Published online Aug 26, 2021. doi: 10.12998/wjcc.v9.i24.7073
Table 1 Main characteristics of included studies in the meta-analysis
Study
Area
Study type
Peptic ulcer (Hp+/Hp-)
Prevalence
Non-ulcer (Hp+/Hp-)
Prevalence
D of Hp
D of LC
Wu et al[11], 1995AsiaCross-sectional23/682.1%59/3264.8%ELISAUltrosound
Kim et al[13], 2008AsiaCross-sectional24/4634.3%76/14234.9%MultipleMultiple
Siringo et al[12], 1997EuropeCross-sectional39/295.1%78/3469.4%ELISAMultiple
Kirchner et al[10], 2011EuropeCross-sectional11/761.1%65/2770.7%ELISAMultiple
Voulgaris et al[16], 2019EuropeCross-sectional9/1047.4%45/3655.6%MultipleMultiple
Wang et al[15], 1997AsiaCross-sectional12/1840.0%7/1236.8%MultipleMultiple
Chen et al[17], 1994AsiaCross-sectional14/1745.2%33/4442.9%ELISAMultiple
Chen et al[18], 1995AsiaCross-sectional9/756.3%18/1652.9%RUTMultiple
Yeh et al[19], 2001AsiaCohort26/1957.8%31/3348.4%UBTMultiple
Hu et al[20], 2002AsiaCross-sectional86/891.5%373/18966.4%MultipleMultiple
Tuo et al[21], 2000AsiaCross-sectional29/4539.2%143/27933.9%MultipleMultiple
Calvet et al[14], 1998EuropeCross-sectional14/670.0%79/9146.5%MultipleMultiple
Zullo et al[9], 1999EuropeCross-sectional51/985.0%84/8250.6%MultipleMultiple
Tsai[5], 1998AsiaCross-sectional54/1084.4%46/2069.7%MultipleMultiple
Table 2 Subgroup analyses and meta-regression
Subcategory
Random-effects model
Meta-regression
n
OR (95%CI)
P value
I2
Ajusted-R2
P value
χ2
Year141.73 (1.16-2.56)< 0.0166.20%4.64%0.24133.29%
Before 200082.19 (1.31-3.67)0.03952.60%
After 2000 (2000)61.34 (0.75-2.38)0.0273.50%
Area141.73 (1.16-2.56)< 0.0166.20%-5.48%0.46736.82%
Asia92.19 (0.81-5.97)0.00179.0%
Europe51.67 (0.56-4.97)0.0974%
Study type141.73 (1.16-2.56)< 0.0166.20%-14.28%0.81739.89%
Cross-sectional study131.75 (1.14-2.70)< 0.0168.7%
Cohort study11.46 (0.68-3.14)
Diagnosis of Hp141.73 (1.16-2.56)< 0.0166.20%-13.83%0.93539.73%
ELISA41.52 (0.62-3.74)0.03664.80%
Multiple81.95 (1.12-3.39)0.00375.30%
RUT11.14 (0.35-3.78)
UBT11.46 (0.68-3.14)
Diagnosis of liver cirrhosis141.73 (1.16-2.56)< 0.0166.20%-11.75%0.81739.01%
Ultrasound11.43 (0.51-3.98)
Multiple131.75 (1.15-2.67)< 0.0168.70%
Case/control ratio141.73 (1.16-2.56)< 0.0166.20%-14.36%0.78739.92%
≥ 0.391.80 (1.11-2.90)0.00960.60%
< 0.351.59 (0.73-3.47)0.00177.90%
Sample size141.73 (1.16-2.56)< 0.0166.20%5.11%0.2433.12%
≥ 100121.89 (1.23-2.91)< 0.0168.70%
< 10020.87 (0.40-1.88)0.5611
Language141.73 (1.16-2.56)< 0.0166.20%-7.60%0.43937.56%
English121.59 (1.05-2.42)0.00558.7%
Chinese22.55 (0.58-11.14)0.00190.6%