Case Report
Copyright ©The Author(s) 2021.
World J Clin Cases. Jan 16, 2021; 9(2): 379-388
Published online Jan 16, 2021. doi: 10.12998/wjcc.v9.i2.379
Table 1 Abnormal findings from laboratory and pathological examinations
Serum tumor markerIncreasedCA19-9
NormalAFP, CA125, CA242, CEA, CYFRA 21-1, NSE, PSA, SCCA
Needle biopsyDiffusely positiveVimentin
Partially positiveEMA, NSE, CK7, CK18, CK (AE1/AE3)
NegativeAFP, CD31, CD34, CgA, CK20, HepPar-1, HMB45, Melan-A, Napsin, S-100, SMA, Syn, TTF-1
Postoperative pathologyDiffusely positiveVimentin, Cam5.2
Partially positiveCK5/6, CK (AE1/AE3), CD10, EMA, Ki-67 (30%)
NegativeCD31, CD34, CD68, CD163, Desmin, HMB45, S-100, SMA
Table 2 Studies involving both spinal metastases of unknown primary tumors and perioperative mortality
No.Ref.YearPeriodCase, nUPT, n (%)Surgery indicationPC, n (%)PM, n (%)
1Morgen et al[33]20132005-20102321549 (23.7)NANANA
2Lee et al[17]20142005-20102005 (2.5)Intractable pain33 (16.5)21 (10.5)
Neurologic deficits
3Quraishi et al[20]20142004-200928517 (6.0)MSCC67 (23.5)NA
4Fehlings et al[34]20162008-201314217 (12.0)Intractable pain42 (29.6)13 (9.0)
Neurologic deficits
Spinal instability
5Wänman et al[15]20172003-20156910 (14.5)MSCC15 (21.7)NA
6Ragel et al[16]20172002-2010454 (8.9)NA19 (42.0)4 (8.9)
7Tan et al[18]20172012-2014192 (10.5)Intractable pain3 (15.8)1 (5.3)
Neurologic deficits
8Yang et al[19]20172002-2014391 (2.6)Severe pain5 (12.8)1 (2.6)
Neurologic deficits
Fracture with displacement
Failure of nonoperative treatment
Histological diagnosis
9Lau et al[29]20172005-20119710 (10.3)Intractable pain20 (20.6)1 (1.0)
Neurological deficit
Spinal instability
10Uei et al[35]20182012-2015551 (1.8)Intractable painNA3 (5.5)
Neurologic deficits
Spinal instability
11Wright et al[6]20181991-20161938156 (8.0)Symptomatic metastasisNANA
12Abdelbaky et al[36]20182008-20137010 (14.3)Intractable pain10 (14.3)3 (4.3)
Neurological deficit
Histological diagnosis
Spinal instability
13Czigléczki et al[37]20182008-201533730 (8.9)NA135 (40.1)26 (7.6)