Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report

Table 1 Clinicopathologic features of 15 pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma cases

Case	Ref.	Gender/age in yr	Primary location	Other locations	BM	Stage	Treatment	Follow up in mo	Outcome
1	Beltran et al[23] (2009)	Female/13	Left cervical LN	Axillary and mediastinal LN, costal bone	No	IIB	LNH96-2002	62	AWD
2	De Paepe et al[24] (2003)	Male/10	Cervical Mass		No	Ⅱ	SFOP-LMB 96 (group B)	6	CR
3	De Paepe et al[24] (2003)	Female/13	Cervical LN	Mediastinal mass, spleen, liver	No	Ⅱ	NHL-BFM ALCL99 with ALCL relapse, autologous BMT	3	PR.DOD
4	Delsol et al[1] (1997)	Male/15	Peripheral LN		No	I	COPAD-Ara-C	156	AWD
5	Laurent et al[19] (2009)	Male/14	Nasal tumor		No	IE	CHOP-derived regimens	5	AWD
6	Laurent et al[19] (2009)	Male/14	Cervical LN		No	I	CHOP-derived regimens	13	AWD
7	Laurent et al[19] (2009)	Male/15	Cervical LN		No	I	CHOP-derived regimens	180	AWD
8	Gesk et al[25] (2005)	Male/13	Cervical LN		No	Ⅱ	ALCL99 protocol (standard-risk group)	NA	PR
9	Gesk et al[25] (2005)	Female/12	Mediastinal mass	Cervical LN	No	Ⅱ	Multiagent chemotherapy	greater than 48	CR
10	Gesk et al[25] (2005)	Male/16	Mediastinal mass	Cervical LN, left pleura, chest wall	Yes	IV	Multiagent chemotherapy, BMT	12	DOD
11	Isimbaldi et al[26] (2006)	Female/9	Left cervical mass	Multiple LNs at diagnosis; Relapsed at the initial site with BM, scalp, liver, spleen, and kidney involvement	NA at diagnosis; Yes, at relapse	NA at diagnosis; IV at relapse	AIEOP LNH 97 protocol; ICE, PVDA	9	CR. relapsed; DOD
12	Bubała et al[27] (2006)	Male/9	Cervical, axillary, and supraclavicular LN and supraclavicular lymph gland	Mediastinal mass, LN along the aorta and in the left iliac fossa, bone	No	Ⅲ	LMB 89, RT	5	DOD
13	Onciu et al[14] (2003)	Male/16	Scalp and parietal bone	Cervical, axillary, and inguinal LN, multiple lytic skeletal lesions	Yes	IV	LMB 89	24	CR. relapsed; DOD
14	Onciu et al[14] (2003)	Male/10	Laryngeal supraglottic mass	Cervical and submandibular LN	No	Ⅱ	POG8719, RT, 3 DAHP courses	156	CR
15	Pan et al[2] (2017)	Male/18	Axillary LN		NA	NA	NA	11	DOD

Case 3 was originally diagnosed as null-type anaplastic large cell lymphomas and achieved complete remission after being treated with LACL-99 HR regimen chemotherapy. Anaplastic lymphoma kinase-positive large B-cell lymphoma was conclusively diagnosed after recurrence. AWD: Alive without disease; BM: Bone marrow; BMT: Bone marrow transplant; CHOP-derived regiments: Cyclophosphamide, doxorubicin, vincristine and prednisone with etoposide or bleomycin; CR: Complete remission; DAHP: Dexamethasone, cytarabine, cisplatin; DOD: Died of disease; ICE: Ifosphamide, carboplatin, etoposide; LN: Lymph node; NA: Not available; NHL-BFM: Non-Hodgkin lymphoma-Berlin-Frankfurt-Munster; PR: Partial remission; PVDA: Prednisone, Vincristine, Doxorubicin, Asparaginase; RT: Radiation therapy to the sites of persistent disease; SFOP-LMB: Société Françaised’ Oncologie Pédiatrique, étude lymphomes B.