Meta-Analysis
Copyright ©The Author(s) 2021.
World J Clin Cases. Jun 16, 2021; 9(17): 4210-4220
Published online Jun 16, 2021. doi: 10.12998/wjcc.v9.i17.4210
Table 1 Population/Patient, Exposure/Intervention, Comparison, and Outcome strategy
PICO or PECO strategy
Description
PPopulation/Patient: Adult patients
EExposure/Intervention: Tranexamic acid
CComparison: Placebo or standard care
OOutcome: Blood loss
Table 2 Studies selected for systematic review and meta-analysis

Ref.
Study design
Sample size
Procedure
Intervention group and control group
1Lei et al[17], 2020RCT132Total knee arthroplastyIV TXA, placebo
2Luo et al[18], 2019RCT90Trochanteric fracture surgeryIV TXA, placebo
3Chen et al[19], 2019RCT166Trochanteric fracture surgeryIV TXA, placebo
4Zhang et al[20], 2019RCT50Total knee arthroplastyTopical TXA, IV TXA
5Zhou et al[21], 2019RCT100Intertrochanteric fracturesTopical TXA (1 g), placebo
6Cvetanovich et al[22], 2018RCT110Total shoulder arthroplastyTXA, placebo
7Huang et al[23], 2017RCT150Total knee arthroplastyTopical TXA (1 g), IV TXA, placebo
8Vara et al[24], 2017RCT102Total shoulder arthroplastyTopical TXA, placebo
9Goyal et al[25], 2017RCT168Total knee arthroplastyTXA, IV TXA
10Chen et al[26], 2016RCT100Total knee arthroplastyTopical TXA, IV TXA
11Drosos et al[27], 2016RCT90Total knee arthroplastyTopical TXA: 1 g, placebo, IV TXA
12Keyhan et al[28], 2016RCT120Total knee arthroplastyTopical TXA: 3 g, placebo, IV TXA (500 g)
13North et al[29], 2016RCT139Total hip replacementTopical TXA: 2 g, IV TXA (2 g)
14Aguilera et al[30], 2015RCT150Total knee arthroplastyTopical TXA: 1 g, IV TXA (2 g), placebo
15Eftekharian et al[31], 2015RCT56Orthognathic surgeryTopical TXA: 1 g, placebo
16Gillespie et al[32], 2015RCT111Total shoulder arthroplastyTopical TXA: 2 g, placebo
17Taheriazam et al[33], 2015RCT80Total hip replacementTopical TXA, IV TXA
18Yang et al[34], 2015 RCT80Total knee arthroplastyTopical TXA, placebo