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©The Author(s) 2021.
World J Clin Cases. Jun 16, 2021; 9(17): 4178-4187
Published online Jun 16, 2021. doi: 10.12998/wjcc.v9.i17.4178
Published online Jun 16, 2021. doi: 10.12998/wjcc.v9.i17.4178
Table 1 Patients’ clinical characteristics
Symptoms | Frequency of symptoms | ||
1st group, n = 56 | 2nd group, n = 14 | 3rd group, n = 12 | |
Constipation | 0 | 14/100 | 3/25 |
Mushy stools | 36/64.2 | 0/0 | 8/66.7 |
Watery stool | 13/23.2 | 0/0 | 0/0 |
Constipations alternating with diarrhea | 39/69.7 | 0/0 | 9/75 |
Stool frequency 1-5 times/d | 51/91.0 | 0/0 | 10/100 |
Stool frequency 5-10 times/d | 5/8.9 | 0/0 | 0/0 |
Stool frequency more than 10 times/d | 1/1.7 | 0/0 | 0/0 |
Abdominal pain | 36/64.2 | 8/57.1 | 9/75.0 |
Weakness | 14/25.0 | 3/21.4 | 2/16.7 |
Rumbling in the abdomen | 40/71.4 | 9/64.2 | 12/100 |
Abdominal bloating | 30/53.5 | 8/57.1 | 11/91.6 |
Table 2 Specificity, sensitivity, and area under the curve of the enzymes
Disaccharidase | Cut-off | Sensitivity (%) | Specificity (%) | AUC |
Glucoamylase | 159.5 | 96 | 84 | 0.9 |
Maltase | 846 | 80 | 70 | 0.8 |
Sucrase | 87.5 | 80 | 82 | 0.9 |
Lactase | 32.5 | 90 | 87 | 0.9 |
Table 3 Enzyme activity in the small intestine mucosa of patients and controls
Group | Carbohydrase activity, ng of glucose/mg tissue × min | |||
Glucoamylase | Maltase | Sucrase | Lactase | |
Control, n = 20 | 490 (231.5-699.25) | 887 (854.5-1146) | 124 (94-210) | 56 (43-77.25) |
1st, n = 56 | 103 (53-141)a | 625 (283-964) | 56 (31-84)a | 10 (6-12)a |
2nd, n = 14 | 116 (44-192.5)a | 571 (415.25-739.5)a | 61.5 (28-158.5)a | 19.5 (3.25-45.5)a |
3rd, n = 12 | 184 (125-236)a | 618 (373-673.75)a | 54.5 (38.75-87)a | 6 (4-20.25)a |
Table 4 Frequency of decreased enzyme activity in the patients
Group | Decrease in enzyme activity | ||||
Glucoamylase | Maltase | Sucrase | Lactase | All disaccharidases | |
1st, n = 56 | 47/83.9 | 30/53.5 | 29/51.7 | 55/98.2 | 21/37.5 |
2nd, n = 14 | 9/64.2 | 5/35.7 | 6/42.8 | 8/57.1 | 3/21.4 |
3rd, n = 12 | 12/100.0 | 5/41.6 | 6/50.0 | 8/66.7 | 2/16.7 |
All, n = 82 | 69/84.1 | 40/48.7 | 41/50.0 | 71/86.5 | 26/31.7 |
- Citation: Dbar S, Akhmadullina O, Sabelnikova E, Belostotskiy N, Parfenov A, Bykova S, Bakharev S, Baulo E, Babanova A, Indeykina L, Kuzmina T, Kosacheva T, Spasenov A, Makarova A. Patients with functional bowel disorder have disaccharidase deficiency: A single-center study from Russia. World J Clin Cases 2021; 9(17): 4178-4187
- URL: https://www.wjgnet.com/2307-8960/full/v9/i17/4178.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v9.i17.4178