Observational Study
Copyright ©The Author(s) 2021.
World J Clin Cases. Jun 16, 2021; 9(17): 4178-4187
Published online Jun 16, 2021. doi: 10.12998/wjcc.v9.i17.4178
Table 1 Patients’ clinical characteristics
Symptoms
Frequency of symptoms
1st group, n = 56
2nd group, n = 14
3rd group, n = 12
Constipation014/1003/25
Mushy stools36/64.20/08/66.7
Watery stool13/23.20/00/0
Constipations alternating with diarrhea39/69.70/09/75
Stool frequency 1-5 times/d51/91.00/010/100
Stool frequency 5-10 times/d5/8.90/00/0
Stool frequency more than 10 times/d1/1.70/00/0
Abdominal pain36/64.28/57.19/75.0
Weakness14/25.03/21.42/16.7
Rumbling in the abdomen40/71.49/64.212/100
Abdominal bloating30/53.58/57.111/91.6
Table 2 Specificity, sensitivity, and area under the curve of the enzymes
Disaccharidase
Cut-off
Sensitivity (%)
Specificity (%)
AUC
Glucoamylase159.596840.9
Maltase84680700.8
Sucrase87.580820.9
Lactase32.590870.9
Table 3 Enzyme activity in the small intestine mucosa of patients and controls
Group
Carbohydrase activity, ng of glucose/mg tissue × min
Glucoamylase
Maltase
Sucrase
Lactase
Control, n = 20490 (231.5-699.25)887 (854.5-1146)124 (94-210)56 (43-77.25)
1st, n = 56103 (53-141)a625 (283-964)56 (31-84)a10 (6-12)a
2nd, n = 14116 (44-192.5)a571 (415.25-739.5)a61.5 (28-158.5)a19.5 (3.25-45.5)a
3rd, n = 12184 (125-236)a618 (373-673.75)a54.5 (38.75-87)a6 (4-20.25)a
Table 4 Frequency of decreased enzyme activity in the patients
Group
Decrease in enzyme activity
Glucoamylase
Maltase
Sucrase
Lactase
All disaccharidases
1st, n = 5647/83.930/53.529/51.755/98.221/37.5
2nd, n = 149/64.25/35.76/42.88/57.13/21.4
3rd, n = 1212/100.05/41.66/50.08/66.72/16.7
All, n = 8269/84.140/48.741/50.071/86.526/31.7