Case Report
Copyright ©The Author(s) 2021.
World J Clin Cases. May 26, 2021; 9(15): 3668-3674
Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3668
Table 1 Targeted next-generation sequencing of 520 cancer-related genes revealed highly concordant mutation profiles of specimens from the primary sigmoid cancer, lung metastasis, and pancreatic resection
Mutated gene and impact on protein sequence
Primary sigmoid cancer
Lung metastasis
Pancreatic resection
KRAS p.G12A+++
TP53 p.R248W+++
TP53 p.C275Y+++
APC p.E893*+++
APC p.L1488fs+++
PTEN p.T319fs+++
FBXW7 p.E664*+++
FBXW7 p.G597R+++
PIK3C2G p.V508A+++
LRP1B p.A3643D+++
PIK3CA p.G118D+
ERCC5 p.T105M+
FAT3 p.S1086G++
TSHR p.D487N++
ASXL1 p.G668S+
INHBA p.K198N+
FGF3 p.A87S+
INPP4B p.K891M+
MITF p.I220L+
EZH2 p.D730fs+
LRP1B p.P1191T+
GNAS amplification+
DAXX amplification+