Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level: A case report

Table 1 Evolution of clinical disease activity, laboratory exams, and clinical treatment

	Day 1 (at hospital admission)	Day 4	Day 8	Day 15	Day 21	Day 51	After 6 mo
Partial Mayo score (points)	9	7	7	7	3	2	0
Mayo endoscopic score (points)	3	-	-	-	-	-	0
Hematocrit/hemoglobin, (%)/(g/dL)	25.8/8.11	27.1/8.61	35.6/11.9	34.4/10.8	32.3/10.6	28.9/9.4	40.2/13.8
C-reactive protein (hs-CRP) (< 1.0mg/dL)	20.3	6.0	2.9	3.7	2.7	-	0.0
Albumin (g/dL)	-	1.9	1.9	2.1	2.1	3.5	4.4
Fecal calprotectin (< 30 μg/g)	-	-	-	921	-	166	-
Infliximab trough level (μg/mL)	-	-	-	8.8	> 20	9.1	-
Medical treatment		Hydrocortisone 300 mg/d + oral vancomycin 250 mg qid	Infliximab 5 mg/kg (first infusion) + hydrocortisone300 mg/d	Infliximab 5 mg/kg (second infusion) + hydrocortisone 100 mg/d. Discharge with azathioprine + prednisone 40 mg	Infliximab 5 mg/kg + azathioprine (third infusion) + corticosteroid tapering	Infliximab 5 mg/kg + azathioprine (fourth infusion) + prednisone 20 mg (dose tapering)	Infliximab 5 mg/kg + azathioprine (maintenance treatment)

¹Blood transfusions.