Melatonin for an obese child with MC4R gene variant showing epilepsy and disordered sleep: A case report

Table 1 Laboratory test results before and after melatonin treatment

Factor	Time (normal as reference)	Before melatonin treatment	After melatonin treatment (7 mo later)
Melatonin (pg/mL)	8:00 (< 5)	10.56a ↑	23.414a ↑
	12:00 (< 5)	2.86	10.677a ↑
	16:00 (< 5)	3.935	4.261
	22:00 (> 10)	4.107a ↓	464.298
ACTH (pmol/L)	0:00 (0-8.7)	3.04	1.46
	8:00 (2.31-18)	8.75	2.66
	16:00 (1.7-16.7)	4.35	4.08
Cortisol (nmol/L)	0:00 (0-165.7)	25.7	82.66
	8:00 (98.7-797.5)	431.52	101.28
	16:00 (85.3-495.6)	223.87	131.95
Triglyceride (mmol/L)		0.79	0.95
Total triiodothyronine (pmol/L)		6.11	6.14
Total tetraiodothyronine (pmol/L)		13.74	14.54
Thyroid-stimulating hormone (mU/L)		3.13	3.05
Cholesterol (mmol/L)		4.54	2.97
Blood glucose (mmol/L)		4.5	4.22
Rorher index		186.98a ↑	186.52a ↑

ACTH: Adrenocorticotropic hormone.

^aP < 0.05.