Retrospective Study
Copyright ©The Author(s) 2021.
World J Clin Cases. Jan 6, 2021; 9(1): 71-80
Published online Jan 6, 2021. doi: 10.12998/wjcc.v9.i1.71
Table 1 Characteristics of the nine patients who received an iodine-131 scan within 1 year before the diagnosis of lung cancer
Patient
Age/gender
Histological type of thyroid cancer
Stage of thyroid cancer
Histological type of lung cancer
Tumor size of lung cancer
Stage of lung cancer
Interval between thyroid cancer and lung cancer diagnosis
Indication and dose of 131I
Interval between 131I administration and lung cancer histological confirmation
131I uptake in lung cancer
NIS expression in lung cancer (staining intensity/percentage)
150/FPapillaryT1aN0bM0Adenocarcinoma1.7 cmT1bN0M01.5 yrElevated Tg antibody level/30 mCi5.7 moPositiveWeak/60%
250/FPapillaryT1bN0bM0Adenocarcinoma2.5 cmT1bN1M015.3 yrThyroid remnant ablation/30 mCi11.3 moNegativeWeak/15%
347/MPapillaryT2N1aM0Adenocarcinoma2.4 cmT2aN0M1a0.2 yrElevated Tg level/100 mCi1.2 moNegativeWeak/10%
444/FPapillaryTxN0bM0Adenocarcinoma3.2 cmT4N3M018.4 yrNeck sonography suggesting tumor recurrence/200 mCi1.8 moNegativeNegative
566/FPapillaryTxN0bM0Adenocarcinoma2.4 cmT2aN1M010.2 yrThyroid cancer surveillance/2 mCi1.7 moNegativeNegative
667/MPapillaryT1bN1bM0Adenocarcinoma3.8 cmT4N2M03.0 yrElevated Tg level/200 mCi3.1 moNegativeNegative
755/FPapillaryT2N1bM0Adenocarcinoma3.0 cmT1cN0M00.3 yrThyroid remnant ablation/30 mCi0.8 moNegativeNegative
856/FPapillaryT3aN1aM1Adenocarcinoma1.8 cmT2aN2M07.6 yrElevated Tg level/100 mCi3.1 moNegative
969/MPapillaryT1aN0bM0Non-small cell lung carcinoma-not otherwise specified4.3 cmT2bN2M01.0 yrElevated Tg level/30 mCi6.5 moNegativeNegative
Table 2 Radioiodine accumulation in primary lung cancers in the literature
Case
Author/year
Age/gender
Histological type of thyroid cancer
Dose of 131I
Histological type of lung cancer
1Fernandez-Ulloa et al[21]/ 197654/MNo primary thyroid cancer identifiedNot reportedAdenocarcinoma
2Acosta et al[22]/198257/FNo primary thyroid cancer identifiedNot reportedLarge cell undifferentiated carcinoma
3Langsteger et al[23]/199064/MPapillary thyroid cancer5 mCiModerately-differentiated tubular adenocarcinoma
4Haubold-Reuter et al[24]/ 1993Not reportedPapillary thyroid cancer20 mCiSmall to medium cell undifferentiated bronchial carcinoma
5Misaki et al[25]/199471/MPapillary thyroid cancer120 mCiSquamous cell carcinoma
6Malhotra et al[26]/200852/MFollicular thyroid cancer182 mCiMucinous bronchoalveolar carcinoma