Myeloid neoplasm with eosinophilia and rearrangement of platelet-derived growth factor receptor beta gene in children: Two case reports

Table 1 Literature review of children diagnosed with myeloid neoplasm with eosinophilia and platelet-derived growth factor receptor beta rearrangement and treated with imatinib

Diagnosis	Age	Sex	Karyotype	Dose of imatinib	Duration to complete remission	Clinical character	Ref.
MDS/MPD syndrome with eosinophilia	11 mo	Female	t(1;5)(q23;q33)	-	5 mo	Anemia, leukocytosis eosinophilia, and thrombocytopenia hepatosplenomegaly.	Wilkinson et al[5]
JMML	Newborn	Male	t(1;5) q21;q33)	370 mg/m2	1 mo	Leukocytosis with eosinophilia, thrombocytopenia and anemia hepatomegaly,	Abraham et al[6]
CEL	8 yr	Male	t(1;5)(q21; 33)	200mg/m2 daily	1 mo	Anemia and leukocytosis eosinophilia, hepatosplenomegaly.	Li et al[7]
Myeloid neoplasms associated with the PDGFRB rearrangement	1mo	Male	t(1;5) (q21; 33)	340 mg/m2/d---170 mg/m2/d	1 mo	Anemia and leukocytosis eosinophils, hepatosplenomegaly.	Abraham et al[8]
Myeloid neoplasms associated with the PDGFRB rearrangement	4 yr	Male	Not clear	340 mg/m2/d---145 mg/m2/d	1 mo	Leukocytosis; eosinophils hepatosplenomegaly.	Abraham et al[8]
Myeloid neoplasms associated with the PDGFRB rearrangement	19 mo	Male	t(5;14)(q33;q32)	200 mg/m2/d	1 wk	Leukocytosis; eosinophilia, hepatosplenomegaly.	Zhang et al[9]
Myeloid neoplasms associated with the PDGFRB rearrangement	1 yr	Female	Normal	200 mg/m2	1 mo	Leukocytosis; anemia, eosinophilia, hepatosplenomegaly.
Myeloid neoplasms associated with the PDGFRB rearrangement	2 yr	Female	t(1;5)(q21;q33)	200 mg/m2	1 mo	Leukocytosis; anemia, thrombocytopenia, eosinophilia, hepatosplenomegaly, fever, rashes.

CEL: Chronic eosinophilic leukemia; JMML: Juvenile myelomonocytic leukemia; MDS: Myelodysplastic syndrome; MPD: Myeloproliferative disorders; PDGFRB: Platelet-derived growth factor receptor beta.