Granulocyte colony-stimulating factor-producing squamous cell carcinoma of the tongue exhibiting characteristic fluorine-18 deoxyglucose accumulation on positron emission tomography–computed tomography: A case report

Table 1 Progression of laboratorial data

	Frist visit	Administration	PO 1 d	PO 18 d	1st ST	2nd ST	3rd ST
Leukocytes (μL)	21380	24510	15230	14250	77620	59720	145180
Neutrophil (%)	84	83	90	86	98	96	98
CRP (mg/dL)	0.99	5.10	9.68	1.14	5.66	8.70	13.20
G-CSF (pg/mL)		331	63.3	71.6	663	218	1520
IL-6 (pg/mL)		14.6	63.0	6.30	10.3		104

CRP: C-reactive protein; PO: Postoperative; ST: Systemic therapy; 1^st dose of CDDP + cetuximab, 2^nd and 3^rd dose of cetuximab alone; G-CSF: Granulocyte-colony stimulating factor.

Table 2 Cases of granulocyte-colony stimulating factor-producing tumor of the oral cavity

No.	Ref.	Sex	Age	Primary site	TN classi-fication	Histological type	Deffrentia-tion	Treatment	Outcome	Survival time (mo)
1	Current research	F	58	Tongue	T3N2c	SCC	Poor	S+Sys.	DOD	1.5
2	Horii et al[14]	M	61	Tongue	T4N0	SCC	Poor	S	DOD	11
3	Kaneko et al[15]	M	57	Tongue	T4aN0	SCC	Moderate	CR+S	DOD	9
4	Kuroshima et al[10]	M	78	Tongue	T3N3	SCC		C	DOD	12
5	Ishigami et al[16]	F	84	Lower gingiva	T2N0	SCC	Poor	R	DOD	2.5
6	Kodama et al[17]	F	71	Lower gingiva	T2N1	MEC		S+CR+C	DOD	1
7	Kobayashi et al[18]	F	56	Lower gingiva	T2N0	SCC	Well	CR+S	DOD	12

SCC: Squamous cell carcinoma; MEC: Mucoepidermoid carcinoma; S: Surgery; C: Chemotherapy; R: Radiotherapy; CR: Chemoradiotherapy; Sys: Systemic therapy; DOD: Death of the disease.