Efficacy of totally laparoscopic compared with laparoscopic-assisted total gastrectomy for gastric cancer: A meta-analysis

Table 1 Baseline characteristics of the included studies

Ref.	Nation	Publication year	Sample size		Age (years, mean ± SD)		BMI (kg/m2, mean ± SD)		NOS scores
			TLTG	LATG	TLTG	LATG	TLTG	LATG
Kim et al[13]	Korea	2013	90	23	58 ± 10.8	56.8 ± 14.2	23.2 ± 2.9	22.2 ± 1.8	7
Ito et al[20]	Japan	2014	117	46	/	/	/	/	6
Kim et al[14]	Korea	2016	27	29	60.8± 9.1	59.3 ± 13.1	24 ± 2.9	23.3 ± 3.2	7
Kim et al[15]	Korea	2016	30	24	51 ± 12.25	54.75 ± 11.25	22.2 ± 2.7	23.6 ± 2.95	8
Chen et al[16]	China	2016	108	145	59.4± 11.1	57.3 ± 12.5	23.5 ± 3.5	23.1 ± 4.2	8
Gong et al[19]	Korea	2017	421	266	57.78± 11.2	55.69 ± 11.96	/	/	7
Huang et al[17]	China	2017	51	456	55.5± 12.1	61.6 ± 11.2	22.5 ± 13.1	22.3 ± 13.5	7
Lu et al[18]	China	2017	25	25	59 ± 8.9	58.4 ± 7.7	22.5 ± 2.5	22.9 ± 3.7	8

TLTG: Totally laparoscopic total gastrectomy; LATG: Laparoscopic-assisted total gastrectomy; SD: Standard deviation; BMI: Body mass index; NOS: The Newcastle–Ottawa Scale.

Table 2 Intraoperative and postoperative information in all included studies

Outcomes	Number of studies	Sample size		Heterogeneity(P, I2)	Effectmodel	Overall effect size	95%CI of overall effect	P value
		TLTG	LATG
Operation time (min)	7	448	748	0.29, 18%	R	WMD = -4.84	-11.62-1.95	0.16
Anastomotic time (min)	2	135	174	0.009, 85%	R	WMD = 9.36	-1.32-20.04	0.09
Tumor size (cm)	7	752	968	0.009, 65%	R	WMD = -0.43	-0.89-0.04	0.07
Proximal margin (cm)	5	611	489	< 0.001, 87%	R	WMD = -0.56	-1.39-0.27	0.18
Intraoperative blood loss (mL)	6	358	725	< 0.001, 76%	R	WMD = -35.37	-61.69--9.06	0.008
Number of lymph nodes removed	6	727	943	0.06, 52%	R	WMD = 3.11	0.63-5.60	0.01
Postoperative VAS pain scores
Peak pain score	2	511	289	0.09, 66%	R	WMD = 0.17	-0.71-1.05	0.70
POD #1 (8 am)	3	541	313	0.73, 0%	R	WMD = -0.01	-0.22-0.19	0.89
POD #3 (8 am)	3	541	313	0.02, 73%	R	WMD = -0.17	-0.61-0.27	0.45
POD #5 (8 am)	2	451	290	0.40, 0%	R	WMD = -0.19	-0.39-0.01	0.07
Time to first flatus (d)	5	301	678	0.41, 0%	R	WMD = 0.07	-0.09-0.22	0.40
Time to first oral intake (d)	6	331	702	0.16, 37%	R	WMD = -0.31	-0.67-0.06	0.10
Postoperative hospital stay (d)	6	331	702	0.18, 34%	R	WMD = -0.78	-1.74-0.19	0.11
Anastomosis-related complications	8	869	1014	0.29, 18%	R	OR = 0.73	0.38-1.40	0.34
Overall postoperative complications	6	701	512	0.57, 0%	R	OR = 1.00	0.75-1.32	0.97

TLTG: Totally laparoscopic total gastrectomy; LATG: Laparoscopic-assisted total gastrectomy; F: Fixed; R: Random; WMD: Weighted mean difference; OR: Odds ratio; CI: Confidence interval; VAS: Visual analog scale; POD: Postoperative day.