Clinicopathologic characteristics of prostatic stromal sarcoma with rhabdoid features: A case report

Table 1 Clinical and histopathologic characteristics of prostatic stromal sarcoma with rhabdoid features

Ref.	Age in yr	Clinical presentation	Pattern of H and E	Pattern of IH	Treatment	Outcome
Yokota et al[4]	45	Hematuria, dysuria, episodes of intermittent fever	Striking proliferation of undifferentiated cells of mesenchymal type with round and spindle-shaped nuclei were shown in the stroma; PAS stain was positive	PSA (+)	Colostomy	Recurrence with death 4 mo after surgery
De Raeve et al[1]	36	Recurrent urinary obstruction	Phyllodes, cystically dilated ducts; Spindle-shaped tumor cells; Fascicularis, mitotic figures (more than 38/10 HPF); Well-differentiated rhabdomyoblasts	Rhabdomyoblastic cells: muscle specific actin (+), desmin (+), myoD1 (+); Stromal tumor cells: Ki-67 (+), CD34 (-), α-SMA (-), desmin (-), actin (-)	Prostatectomy followed by chemotherapy and radiotherapy	Recurrence after prostatectomy 4 mo later
Herawi et al[3]	N/A	N/A	Focal rhabdomyosarcomatous differentiation	Rhabdomyoblastic cells: desmin (+), myogenin (+)	N/A	N/A
Kim et al[2]	31	Voiding difficulty and anal pain	Biphasic growth pattern with spindle and epithelioid cells, highly cellular spindle tumor cells with focal nuclear pleomorphism; Focal cells with rhabdoid features	Spindle cells and epithelioid tumor cells: vimentin (+), CD34 (+), progesterone receptors (+), INI1 (+); Rhabdoid cells: INI1 (+)	Radical prostatectomy followed by cystectomy	Recurrence, with death 3 mo after cystectomy
Current case	34	Hematuria and progressive dysuria	Huge number of atypia spindle cells; Poor differentiation of embryonoid rhabdomyoblasts with abundant eosinophilic cytoplasm	Spindle cells: vimentin (+), β-catenin (+); Rhabdomyoblastic cells: MyoD1 (+), myogenin (+) INI1 (+); Epithelioid cells: PSA (+)	Transurethral prostatectomy	Died of uncontrollable tumor and severe bleeding 3 mo after surgery

H and E: Hematoxylin and eosin; IH: Immunohistochemical; INI1: Integrase interactor 1; MyoD1: Myoblast determination protein 1; N/A: Data not available; PSA: Prostate-specific antigen; SMA: Smooth muscle actin.