Isolated vaginal metastasis from stage I colon cancer: A case report

Table 1 Summary of the reported cases of vaginal metastasis from colorectal cancer

No	Age (yr)	Location	Stage	Synchro-nous meta-stasis1	Time interval	Treatment for VM2	Isolated VM3	Metachro-nous metastasis	Outcome	Ref.
1	52	SC	NM	No	Sync	TVE, cervicectomy, IRT	Yes	-	39 mo, Dead	Whitelaw et al[4]
2	46	DC	Dukes B	No	13 mo	IRT	No	Peritoneum, omentum, brain	39 mo, Dead	Raider et al[5]
3	48	SC	Dukes C	Ovaries, uterus	4 mo	IRT	No	Pleura, liver	21 mo, Dead	Raider et al[5]
4	63	RS	Dukes C	No	21 mo	TVE, nitrogen mustard→ EBRT, IRT	Yes	-	48 mo, NED	Raider et al[5]
5	46	RS	Dukes C	No	41 mo	EBRT, IRT	No	Ovary, ileum, peritoneum, media-stinum	10 mo, Dead	Raider et al[5]
6	81	RS	T3N+	No	Sync	TVE	Yes	-	12 mo, NED	Lee et al[16]
7	57	SC	T?N+	No	18 mo	IRT → observation	Yes	-	12 mo, NED	Lee et al[16]
8	56	DC	T4N1	Peritoneum	Sync	Partial resection	No	Peritineum	8 mo, AWD	Singh et al[17]
9	83	SC	T4N1	No	3 wk	NM	No	Liver, skin	NM	Chagpar et al[18]
10	44	Rec	T3N1	Liver	13 mo	Incisional Bx., IRT, CTx	No	-	NM	Yagci et al[19]
11	81	SC	T4N0	No	Sync	TVE, TAH/BSO, EBRT, IRT	Yes	-	39 mo, NED	Marchal et al[20]
12	67	AC	T4N0	No	3 mo	TVE, EBRT	Yes	-	48 mo, NED	Costa et al[21]
13	63	Rec	NM	No	Sync	Partial resection, EBRT	Yes	-	12 mo, NED	Funada et al[22]
14	72	Rec	T4N2	No	Sync	TVE, BO, CTx	Yes	-	13 mo, NED	Ceccaroni et al[23]
15	64	SC	T?N1	No	34 mo	En-bloc resection (Vagina partial resection, TAH/BSO, radical cystectomy)	No	Brain	10 mo, Dead	Lorente et al[24]
16	62	Rec	NM	No	Sync	TVE	Yes	-	12 mo, NED	Sabbagh et al[25]
17	78	Rec	uT3N0	No	Sync	TVE, CTx, EBRT	Yes	-	10 mo, NED	Sabbagh et al[25]
18	53	RS	T3N2	No	24 mo	CTx, EBRT	No	Peritoneum, systemic LNs	24 mo, AWD	Macedo et al[26]
19	64	SC	T4N0	No	36 mo	EBRT	No		8 mo, NED	Tanaka et al[27]
20	67	SC	T3N0	No	Sync	TVE	Yes		NM	D'Arco et al[8]
21	87	Rec	T4N?	No	24 mo	EBRT	Yes		NM, AWD	Ng et al[9]
22	78	Rec	T4N1	No	Sync	TVE, TAH/BSO	No		22 mo, AWD	Sadatomo et al[6]
23	63	SC	T2N0	No	10 mo	TVE→ TVE	Yes		47 mo, NED	This case

¹Metastasis to other organs except for the vagina.

²“→” indicates that additional treatment was conducted because of vaginal recurrence.

³The vagina is the only metastatic site during the follow-up period. VM: Vaginal metastasis; NM: Not mentioned; Sync: Synchrounous; DC: Descending colon; SC: Sigmoid colon; RS: Rectosigmoid junction; Rec: Rectum; AC: Ascending colon; TAH/BSO: Total abdominal hysterectomy with bilateral salpingo-oophorectomy; BO: Bilateral oophorectomy; TVE: Transvaginal excision; CTx: Chemotherapy; EBRT: External beam radiotherapy; IRT: Internal radiotherapy; Bx: Biopsy; LNs: Lymph nodes; NED: No evidence of disease; AWD: Alive with disease.