Gallbladder sarcomatoid carcinoma: Seven case reports

Table 1 Chief complaints

Characteristic	No recurrence		Recurrence or metastasis
	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7
Age	83	79	50	51	76	65	76
Sex (F/M)	M	F	F	F	F	F	F
Duration of pain	1 mo	6 mo	4 yr	1 mo	1 mo	20 d	2 mo

M: Male; F: Female.

Table 2 Laboratory examinations

	No recurrence		Recurrence or metastasis
	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7
DBIL	12.2↑	4.5	3.8	7.2	3.3	5.6	3.8
ALT	11	10	10	75↑	18	8	38
AST	21	15	21	62	22	14	25
CEA	1.05	1.37	N/A	2.54	47.4↑	0.29	5.74↑
CA19-9	22.7	19.46	125↑	> 1000↑	446.8↑	7.8	24.42
CA-125	40.12	7.19	102.1↑	115.8↑	N/A	43.77	272.3↑
AFP	4.15	1.94	0.69	8.77	3.22	0.79	N/A

DBIL: Direct bilirubin; ALT: Alanine transaminase; AST: Aspartate transaminase; CA19-9: Carbohydrate antigen; CEA: Carcinoembryonic antigen; AFP: Alpha-fetoprotein; N/A: Not available.

Table 3 Tumor characteristics

Characteristic	No recurrence		Recurrence or metastasis
	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7
Position	Body and choledochus	Body	Body	Fundus and neck	Body	Body	Fundus
Diameter	3 cm	7.2 cm	7 cm	7 cm	9 cm	10 cm	7 cm
Operation	P	R	R	R	R	R (colon)	P
Depth	T1	T2	T2	T3	T3	T3	T3
Lymph node	N01	N0	N1	N2	Nx	N2	Nx
Metastasis	M0	M0	M0	M0	M0	M0	M1
Stage	I	II	IIIB	IVB	III/IV	IVB	IVB

¹Preoperative magnetic resonance imaging evaluation. R: Radical surgery; P: Palliative cholecystectomy.

Table 4 Pathological diagnosis

	No recurrence		Recurrence or metastasis
	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7
Carcinoma	Adenocarcinoma	NM	NM	Adenosquamous	Adenosquamous	Adenocarcinoma	Adenocarcinoma
PCK	(+)	(+)	(+)	(+)	(+)	(+)	(+)
Cytokeratin	CK19+	CK7 (+), CK20 (-)	CK19 (focal+), CK7 (-)	CK7 (+), CK19 (+)	NT	CK7 (focal+), CK20 (focal+)	NT
EMA	NT	(+)	(focal +)	NT	NT	+	NT
Vimentin	NT	NT	NT	NT	NT	(focal +)	NT
Desmin	(-)	(-)	(-)	(-)	(-)	(-)	(-)
a-SMA	(-)	(-)	NT	(-)	(-)	(-)	(-)
Other positive markers		S-100 (±)		P63 (focal +)		CAM5.2 (focal +)
Other negative markers	Syn (-), CgA (-)			HCC (-), CD34 (-)		DOG1 (-), CD117 (-), CD34 (-)

NM: Not mentioned; NT: Not tested; PCK: Pan-cytokeratin.

Table 5 Prognosis

	No recurrence		Recurrence or metastasis
	Case 1	Case 2	Case 3	Case 4	Case 5	Case 6	Case 7
Stage	I	II	IIIB	IVB	III/IV	IIIB	IVB
Adjuvant therapy	No	No	Yes	No	No	No	No
Recurrence or metastasis	No	No	Liver and bone	Liver	Liver	Liver	Peritoneum
PFS	> 5 yr	> 3 yr	12 mo	2 mo	2 mo	1 mo	-
OS	> 5 yr	> 3 yr	15 mo	2.6 mo	2.5 mo	2 mo	1.8 mo

PFS: Progression-free survival; OS: Overall survival.